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Ultrasound Therapy

VS tFUS/Sham tFUS for Impulsivity

N/A
Recruiting
Led By Mary Phillips, MD, MD
Research Sponsored by Mary Phillips, MD MD (Cantab)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30-60 minutes
Awards & highlights

Study Summary

This trial will study how ultrasound on the brain affects emotions, in hopes of understanding substance abuse better. #Research

Who is the study for?
This trial is for healthy adults aged 18-35 with no psychiatric history. Participants must not have a developmental disorder, seizure disorder, substance use disorders (except cannabis), or neurological issues. They should score above 24 on the MMSE and have an IQ estimate over 85. Pregnant individuals, those with visual impairments, metal implants, claustrophobia or left/mixed handedness are excluded.Check my eligibility
What is being tested?
The study tests the immediate effects of transcranial focused ultrasound (tFUS) on brain activity and emotions in participants without any mental health conditions. It's a preliminary step to understand brain mechanisms that could predispose people to substance use disorders.See study design
What are the potential side effects?
While tFUS is generally considered safe, potential side effects may include discomfort at the treatment site, headache, nausea or mood changes immediately following treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30-60 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30-60 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood oxygen level-dependent (BOLD) signal

Trial Design

2Treatment groups
Experimental Treatment
Group I: VS tFUS/Sham tFUSExperimental Treatment2 Interventions
VS tFUS (tFUS applied to the ventral striatum) Sham tFUS (go through the motions of applying tFUS to the VS)
Group II: Sham tFUS/VS tFUSExperimental Treatment2 Interventions
VS tFUS (tFUS applied to the ventral striatum) Sham tFUS (go through the motions of applying tFUS to the VS)

Find a Location

Who is running the clinical trial?

Mary Phillips, MD MD (Cantab)Lead Sponsor
2 Previous Clinical Trials
160 Total Patients Enrolled
Mary Phillips, MD, MDPrincipal InvestigatorUniversity of Pittsburgh
1 Previous Clinical Trials
134 Total Patients Enrolled
Fabio Ferrarelli, MD, PhDPrincipal InvestigatorUniversity of Pittsburgh
3 Previous Clinical Trials
235 Total Patients Enrolled

Media Library

tFUS (Ultrasound Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05875181 — N/A
Impulsivity Research Study Groups: VS tFUS/Sham tFUS, Sham tFUS/VS tFUS
Impulsivity Clinical Trial 2023: tFUS Highlights & Side Effects. Trial Name: NCT05875181 — N/A
tFUS (Ultrasound Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05875181 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must an individual meet to be considered for participation in this experiment?

"The study is welcoming up to 5 applicants who demonstrate impulsive behaviour and are between 18-35 years old."

Answered by AI

How many participants are currently enrolled in this clinical research?

"That is accurate. According to clinicaltrials.gov, this research project commenced on June 1st 2023 and was recently amended on May 15th of the same year. Five participants are needed from one medical site."

Answered by AI

Is recruitment for this trial still available?

"Affirmative. According to clinicaltrials.gov, this trial is currently accepting participants and was initially posted on June 1st 2023 with the latest update having been made on May 15th 2023. The research requires 5 individuals from a single medical site."

Answered by AI

Is this medical study open to elderly persons aged 85 and older?

"This trial is restricted to those aged 18-35. There are 4 separate clinical trials for minors and 8 more for seniors over the age of 65."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry
Mary Phillips, MD MD (Cantab) 2023. "Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05875181.
~2 spots leftby Dec 2024
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