In our series, only five patients achieved resolution of OHS symptoms. On a group level, overweight patients with OHS benefited less from CPAP therapy. Therefore, CPAP should be prescribed to only lean patients.
Most patients with obstructive sleep apnea show symptomatic improvement with CPAP. The addition of weight loss may improve exercise habits and reduce nocturnal hypoxia, which is an independent risk factor for apnea.
Obesity hypoventilation syndrome has been termed by many different names, and is likely a complex syndrome defined by a collection of features and associated conditions. The medical treatment depends on the specific problem, including whether this is an issue in the primary prevention setting.
Obese patients can have a variety of respiratory complaints including increased work of breathing, rapid shallow breathing pattern, and/or increased dyspnea. Many patients do not have OHS and are not diagnosed with respiratory problems and will be left untreated.
Obesity hypoventilation syndrome (OHS) is characterized by increased alveolar ventilation in the presence of normal lung volumes which is not seen with obstructive [sleep apnea](https://www.withpower.com/clinical-trials/sleep-apnea) (OSA). The central circadian drive that generates arousal from sleep in OSA is not present in OHS. The primary cause of OHS remains unknown. The clinical presentation of OHS may reflect increased sympathetic nervous system activity and increased plasma cortisol levels.
Obesity hypoventilation syndrome is diagnosed in a substantial number of people annually. It is associated with significant morbidity and mortality. This article includes a videotape of an educational session given at the National Obesity Association Convention and Exhibition.
More recent findings show that the ketogenic diet was better than the standard, high-carbohydrate diet in treatment of the adults with the intractable neurodegenerative diseases. Furthermore, the ketogenic diet is well suited to treatment of the conditions caused by congenital diseases, such as epilepsy and muscular dystrophy. It is of major importance to the public, that it is still unclear when will be the ketogenic diet be commercially available. The ketogenic diet is most effective against epileptic seizures which is important to all patients with uncontrolled or intractable epilepsy, for the treatment of children or adults.
Although there were no significant differences between the BD-only group and the BD-co-morbid group based on the mean of the number and the magnitude of the side effects, it seems that a combination of other treatments may be useful to improve the treatment efficacy to treat and prevent the hypoxic episodes in patients with refractory epilepsy.
Obesity hypoventilation syndrome appears in all age groups, more often in men older than 50 years, and less often in African American obese infants or toddlers, and in obese male adolescents.
The data suggest the need to re-evaluate current treatments for OHS, and there is a need for greater research into the role of dietary fat in OHS, including an increase in animal-based research.
This retrospective study supports the notion that a significant number of patients with obesity hypoventilation syndrome may have familial disease. Results from a recent paper underscore the need for intensified prospective screening of members of this syndrome for both obesity and hypoventilation.
The ketogenic diet is not completely free from side effects. The most frequent are gastrointestinal complaints, which may be partially caused by the low insulin levels. To minimize the risk of adverse effects of the diet, it is recommended to have regular blood sugar testing to detect any hypoglycaemic symptoms and to check the levels of insulin, ketones, ketones, and fat in the blood daily. Although the majority of adults who go on the diet do feel some hunger, the short duration of a calorie-restricted diet reduces this to acceptable levels. Some subjects feel some hunger in the early phase of the diet, but they get over it quickly. Patients should use the information as a guide to help them choose the right diet for them.