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Thyroid Hormone Replacement

Levothyroxine for Hypothyroidism (DTE Trial)

N/A
Waitlist Available
Research Sponsored by Walter Reed National Military Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients will be between the ages of 18 to 65 and will have been on levothyroxine for primary hypothyroidism for at least 6 months.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights

DTE Trial Summary

Our hypothesis is that hypothyroid patients on DTE may have a decrease in symptoms, an improvement of cognitive function, and an increase in sense of well-being/ quality of life equivalently compared with L-T4.

Eligible Conditions
  • Hypothyroidism

DTE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

DTE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Wechsler Memory Scale-Version IV (WMS-IV)
thyroid-symptom questionnaire
Secondary outcome measures
Biochemical measures
Other outcome measures
Beck Depression Index
Clinical preference
General health questionnaire-12

DTE Trial Design

2Treatment groups
Active Control
Group I: LevothyroxineActive Control1 Intervention
Levothyroxine in the capsule form, once daily, appropriate dosage to keep TSH at the normal range.
Group II: Desiccated thyroid extractActive Control1 Intervention
Desiccated thyroid extract in capsule form, once daily, appropriate dosage to keep TSH in the normal range.

Find a Location

Who is running the clinical trial?

Walter Reed National Military Medical CenterLead Sponsor
137 Previous Clinical Trials
34,317 Total Patients Enrolled
1 Trials studying Hypothyroidism
81 Patients Enrolled for Hypothyroidism

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Virginia
How old are they?
18 - 65
What site did they apply to?
Walter Reed National Military Medical Center, Endocrinology
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
Archives of General PsychiatryJournal
An Inventory for Measuring Depression
BECK, A. T.. 1961. “An Inventory for Measuring Depression”. Archives of General Psychiatry. American Medical Association (AMA). doi:10.1001/archpsyc.1961.01710120031004.
clinicaltrials.govStudy
Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment
Mohamed K.M. Shakir 2012. "Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01739972.
All > Thyroid
~14 spots leftby Apr 2025
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