Water Dosing for Orthostatic Hypotension
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how drinking water affects individuals with orthostatic hypotension, a condition where blood pressure drops upon standing, causing dizziness. Researchers aim to determine if drinking a full glass of water in the morning continues to raise blood pressure later in the day after an earlier dose. The study includes two groups: one drinks 16 ounces of water in the morning, while the other consumes just 1 ounce. Individuals who frequently experience dizziness or lightheadedness when standing may be well-suited for this trial. As an unphased trial, it offers a unique opportunity to contribute to understanding simple lifestyle changes that might improve daily life for those with this condition.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that water ingestion is safe for patients with orthostatic hypotension?
Research has shown that drinking water is generally safe for people. Water supports many body functions, and most people consume it daily without issues. In this study, participants will drink either 16 ounces or 1 ounce of water, which is a normal and safe amount for most individuals.
No evidence from other studies indicates any major safety concerns with the water amounts used in this trial. Drinking water is common and usually well-tolerated. Such moderate water intake typically does not cause negative effects in healthy individuals.
In summary, based on everyday experiences and the absence of specific safety concerns in similar studies, drinking water in this trial is likely safe.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a simple and accessible approach to managing orthostatic hypotension using water dosing. Unlike typical treatments that often involve medications like fludrocortisone or midodrine, this trial investigates the impact of consuming water as a potential intervention. The key features of this approach include its non-pharmaceutical nature, making it a low-cost and low-risk option. Additionally, water is readily available and could offer a rapid onset of action, providing immediate support to individuals experiencing symptoms of orthostatic hypotension.
What evidence suggests that water ingestion is effective for orthostatic hypotension?
This trial will compare the effects of different water dosages on orthostatic hypotension. Research has shown that drinking water can quickly raise blood pressure in people with this condition, where blood pressure drops upon standing. Participants in one arm of this trial will receive 16 ounces of water, which earlier studies found can noticeably increase blood pressure within minutes. This occurs because water may trigger the release of hormones that tighten blood vessels, raising blood pressure. Although the exact mechanism remains unclear, the quick and significant rise in blood pressure after drinking water is well-documented in people with this condition. Therefore, water is considered an effective immediate treatment for managing low blood pressure symptoms when standing.12678
Who Is on the Research Team?
Satish R Raj, MD MSCI
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 with orthostatic hypotension, which means their blood pressure drops significantly when standing up. They should have previously shown a blood pressure increase after drinking water in other studies. Pregnant individuals cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 1 oz or 16 oz of water in the morning followed by 16 oz of water a few hours later while blood pressure is monitored
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Water
Trial Overview
The study investigates the effect of two different doses of water on blood pressure in patients with orthostatic hypotension. It aims to determine if the pressor (blood-pressure raising) response to water diminishes when a full dose is taken earlier.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
16 oz water in AM
water 1 oz in AM
Find a Clinic Near You
Who Is Running the Clinical Trial?
Satish R. Raj
Lead Sponsor
Published Research Related to This Trial
Citations
Effects of l-citrulline supplementation and watermelon ...
In conclusion, this meta-analysis provided evidence that longer-term l-citrulline and watermelon consumption may improve vascular function in adults, suggesting ...
The Effectiveness of Young Coconut Water and ...
Coconut water, with potassium, and watermelon, with anti-hypertensive content, may help lower blood pressure. The study aims to determine their effect.
Current Evidence of Watermelon (Citrullus lanatus) Ingestion ...
In contrast, watermelon juice supplementation did not affect resting blood pressure in healthy postmenopausal women [9]. Furthermore, watermelon ...
4.
researchgate.net
researchgate.net/publication/269772640_The_effect_of_l_-citrulline_and_watermelon_juice_supplementation_on_anaerobic_and_aerobic_exercise_performanceThe effect of l -citrulline and watermelon juice ...
Results showed that the supplements did not significantly affect the total number of repetitions, fatigue time, VO2 max, and anaerobic threshold ...
5.
aging.networkofcare.org
aging.networkofcare.org/sanmateo/CommunityResources/ClinicalTrials/Detail/NCT04328311?keyword=%22Citrulline%22The Impact of Watermelon Juice on Blood Pressure
Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide.~The study will be an ...
6.
trial.medpath.com
trial.medpath.com/clinical-trial/d4fd7bfc660f3e86/nct04328311-impact-watermelon-juice-blood-pressureThe Impact of Watermelon Juice on Blood Pressure | MedPath
Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide. The study will be an ...
L-Citrulline Supplementation and Exercise in the ...
... watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans. Nitric. Oxide 2016 ...
8.
researchgate.net
researchgate.net/publication/396466633_Watermelon_Nutritional_Composition_with_a_Focus_on_L-Citrulline_and_Its_Cardioprotective_Health_Effects-A_Narrative_Review(PDF) Watermelon Nutritional Composition with a Focus on ...
Herein, this narrative review critically examines current evidence of the cardiovascular benefits of L-citrulline ingestion obtained exclusively ...
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