Water Dosing for Orthostatic Hypotension
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how drinking water affects individuals with orthostatic hypotension, a condition where blood pressure drops upon standing, causing dizziness. Researchers aim to determine if drinking a full glass of water in the morning continues to raise blood pressure later in the day after an earlier dose. The study includes two groups: one drinks 16 ounces of water in the morning, while the other consumes just 1 ounce. Individuals who frequently experience dizziness or lightheadedness when standing may be well-suited for this trial. As an unphased trial, it offers a unique opportunity to contribute to understanding simple lifestyle changes that might improve daily life for those with this condition.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that water ingestion is safe for patients with orthostatic hypotension?
Research has shown that drinking water is generally safe for people. Water supports many body functions, and most people consume it daily without issues. In this study, participants will drink either 16 ounces or 1 ounce of water, which is a normal and safe amount for most individuals.
No evidence from other studies indicates any major safety concerns with the water amounts used in this trial. Drinking water is common and usually well-tolerated. Such moderate water intake typically does not cause negative effects in healthy individuals.
In summary, based on everyday experiences and the absence of specific safety concerns in similar studies, drinking water in this trial is likely safe.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a simple and accessible approach to managing orthostatic hypotension using water dosing. Unlike typical treatments that often involve medications like fludrocortisone or midodrine, this trial investigates the impact of consuming water as a potential intervention. The key features of this approach include its non-pharmaceutical nature, making it a low-cost and low-risk option. Additionally, water is readily available and could offer a rapid onset of action, providing immediate support to individuals experiencing symptoms of orthostatic hypotension.
What evidence suggests that water ingestion is effective for orthostatic hypotension?
This trial will compare the effects of different water dosages on orthostatic hypotension. Research has shown that drinking water can quickly raise blood pressure in people with this condition, where blood pressure drops upon standing. Participants in one arm of this trial will receive 16 ounces of water, which earlier studies found can noticeably increase blood pressure within minutes. This occurs because water may trigger the release of hormones that tighten blood vessels, raising blood pressure. Although the exact mechanism remains unclear, the quick and significant rise in blood pressure after drinking water is well-documented in people with this condition. Therefore, water is considered an effective immediate treatment for managing low blood pressure symptoms when standing.12678
Who Is on the Research Team?
Satish R Raj, MD MSCI
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 with orthostatic hypotension, which means their blood pressure drops significantly when standing up. They should have previously shown a blood pressure increase after drinking water in other studies. Pregnant individuals cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 1 oz or 16 oz of water in the morning followed by 16 oz of water a few hours later while blood pressure is monitored
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Water
Find a Clinic Near You
Who Is Running the Clinical Trial?
Satish R. Raj
Lead Sponsor