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Precursor of Dopamine

Testing on-levodopa for Parkinson's Disease

Phase 2 & 3

Waitlist Available

Research Sponsored by University of Utah

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up outcome measures will be assessed at 1 year

Awards & highlights

Study Summary

This trial will look at how levodopa affects the cardiovascular autonomic function in patients with Parkinson's disease with and without neurogenic orthostatic hypotension.

Eligible Conditions

Parkinson's Disease
Orthostatic Hypotension

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ outcome measures will be assessed at 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~outcome measures will be assessed at 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and outcome measures will be assessed at 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in systolic blood pressure from supine to tilt at 3 minutes

Secondary outcome measures

Validated index of baroreflex cardiovagal function

Validated index of sympathoneural function

Trial Design

2Treatment groups

Experimental Treatment

Group I: Testing on-levodopaExperimental Treatment1 Intervention

Participants will undergo autonomic testing one hour after taking their regular morning dose of levodopa.

Group II: Testing off-levodopaExperimental Treatment1 Intervention

Participants will undergo autonomic testing at least twelve hours after taking their last dose of levodopa.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Autonomic testing on and off levodopa

2022

Completed Phase 3

~40

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor

1,098 Previous Clinical Trials

1,778,590 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the cap on participants in this research initiative?

"Affirmative. Clinicaltrials.gov contains proof that this clinical trial, initially published on May 11th 2022, is currently recruiting individuals to participate in the study. 40 patients are needed from a single medical centre."

Answered by AI

Is recruitment of individuals for this experiment still happening?

"Affirmative. The information hosted on clinicaltrials.gov indicates that this medical trial is actively seeking participants and has so far recruited 40 individuals from a single location. It was posted on May 11th 2022, with its latest update occurring on August 1st 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease

Guillaume Lamotte 2022. "Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05487300.