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Genetic Testing

Family History + Whole Genome Sequencing for Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy

N/A
Waitlist Available
Led By Robert C Green, MD, MPH
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at post-disclosure visit (about 1 hour after results disclosure, avg. 11 mos. after baseline), at 6-weeks post-disclosure, and at 6-months post-disclosure (6 wks follow-up approx. 12.5 mos. and 6 mos. follow-up approx. 17 mos. after baseline)
Awards & highlights

Study Summary

This study is evaluating whether a genetic test can help doctors treat patients.

Eligible Conditions
  • Healthy Adults
  • Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change at 6-weeks post-results disclosure relative to baseline, administered approx.12.5 months after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and change at 6-weeks post-results disclosure relative to baseline, administered approx.12.5 months after baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Attitudes and Trust
Change in General Anxiety and Depression
Change in Health Behaviors
+9 more
Secondary outcome measures
Decisional Regret
Expectations
Psychological Impact
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Family History + Whole Genome SequencingExperimental Treatment1 Intervention
Doctors and their patients receive a Genome Report and an Annotated Family History Report.
Group II: Family History OnlyActive Control1 Intervention
Doctors and their patients receive an Annotated Family History Report only.

Find a Location

Who is running the clinical trial?

Duke UniversityOTHER
2,363 Previous Clinical Trials
3,420,293 Total Patients Enrolled
National Human Genome Research Institute (NHGRI)NIH
263 Previous Clinical Trials
283,919 Total Patients Enrolled
Baylor College of MedicineOTHER
1,001 Previous Clinical Trials
6,002,039 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Brigham and Women's Hospital
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
ScienceJournal
Deflating the Genomic Bubble
Evans, James P., Eric M. Meslin, Theresa M. Marteau, and Timothy Caulfield. 2011. “Deflating the Genomic Bubble”. Science. American Association for the Advancement of Science (AAAS). doi:10.1126/science.1198039.
Clinical GeneticsJournal
Effects of Informed Consent for Individual Genome Sequencing on Relevant Knowledge
Kaphingst, KA, FM Facio, M-R Cheng, S Brooks, H Eidem, A Linn, BB Biesecker, and LG Biesecker. 2012. “Effects of Informed Consent for Individual Genome Sequencing on Relevant Knowledge”. Clinical Genetics. Wiley. doi:10.1111/j.1399-0004.2012.01909.x.
TrialsJournal
The Medseq Project: A Randomized Trial of Integrating Whole Genome Sequencing into Clinical Medicine
Vassy, Jason L, Denise M Lautenbach, Heather M McLaughlin, Sek Won Kong, Kurt D Christensen, Joel Krier, Isaac S Kohane, et al.. 2014. “The Medseq Project: A Randomized Trial of Integrating Whole Genome Sequencing into Clinical Medicine”. Trials. Springer Science and Business Media LLC. doi:10.1186/1745-6215-15-85.
Public Health GenomicsJournal
A One-page Summary Report of Genome Sequencing for the Healthy Adult
Vassy, Jason L., Heather L. McLaughlin, Calum A. MacRae, Christine E. Seidman, Denise Lautenbach, Joel B. Krier, William J. Lane, et al.. 2015. “A One-page Summary Report of Genome Sequencing for the Healthy Adult”. Public Health Genomics. S. Karger AG. doi:10.1159/000370102.
All > Health
~16 spots leftby Apr 2025
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