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MRI for ADHD Treatment Response Prediction

N/A
Waitlist Available
Led By Joseph Biederman, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test if certain brain markers can predict how well adults with ADHD will respond to stimulant medications.

Eligible Conditions
  • Attention Deficit Hyperactivity Disorder (ADHD)

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
ADHD Clinical Global Impressions Scale - Improvement (CGI-I)
ADHD Clinical Global Impressions Scale - Severity (CGI-S)
Secondary outcome measures
Connectomic Variation Prediction of Medicine Response

Trial Design

2Treatment groups
Experimental Treatment
Group I: MethylphenidateExperimental Treatment1 Intervention
Adult subjects (ages 18-45) receiving a Methylphenidate derivative medication
Group II: AmphetamineExperimental Treatment1 Intervention
Adult subjects (ages 18-45) receiving an Amphetamine derivative medication
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI
2009
Completed Phase 2
~1370

Find a Location

Who is running the clinical trial?

Massachusetts Institute of TechnologyOTHER
97 Previous Clinical Trials
12,729,927 Total Patients Enrolled
1 Trials studying Attention Deficit Hyperactivity Disorder (ADHD)
41 Patients Enrolled for Attention Deficit Hyperactivity Disorder (ADHD)
Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,295 Total Patients Enrolled
59 Trials studying Attention Deficit Hyperactivity Disorder (ADHD)
8,479 Patients Enrolled for Attention Deficit Hyperactivity Disorder (ADHD)
Joseph Biederman, MDPrincipal InvestigatorMassachusetts General Hospital
24 Previous Clinical Trials
6,374 Total Patients Enrolled
13 Trials studying Attention Deficit Hyperactivity Disorder (ADHD)
4,444 Patients Enrolled for Attention Deficit Hyperactivity Disorder (ADHD)

Media Library

MRI Clinical Trial Eligibility Overview. Trial Name: NCT03153488 — N/A
Attention Deficit Hyperactivity Disorder (ADHD) Research Study Groups: Amphetamine, Methylphenidate
Attention Deficit Hyperactivity Disorder (ADHD) Clinical Trial 2023: MRI Highlights & Side Effects. Trial Name: NCT03153488 — N/A
MRI 2023 Treatment Timeline for Medical Study. Trial Name: NCT03153488 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this trial inclusive of geriatric patients?

"The minimum age of entry for this trial is 18, while the maximum permitted age is 55."

Answered by AI

Are there still open opportunities for participants in this research project?

"According to the data found on clinicaltrials.gov, this medical trial is not currently taking in candidates. Initially posted July 1st 2018 and most recently updated September 22nd 2022, there are nevertheless 1065 other trials presently accepting participants."

Answered by AI

To what extent is enrollment in this research open?

"This trial seeks 60 participants between 18 and 55 years old with a diagnosis of Attention Deficit Hyperactivity Disorder (ADHD). Qualified applicants must be fluent in English, right-handed, and male or female adults. The presence of ADHD is verified by clinical assessment supplemented by the DSM-V ADHD module from a structured interview."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
Pennsylvania
Other
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
3+

Why did patients apply to this trial?

I was diagnosed late in life. I am currently a research nurse and I am interested in advancing evidence based medicine.
PatientReceived no prior treatments
I’m trying to apply on this form it it won’t let me finish signing it. The screen won’t resize so I can get to the bottom.
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Attention Deficit Hyperactivity Disorder (ADHD) Prediction of Treatment Response
Joseph Biederman, MD 2018. "Attention Deficit Hyperactivity Disorder (ADHD) Prediction of Treatment Response". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03153488.
All > Adhd
~9 spots leftby Apr 2025
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