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Behavioural Intervention

Laryngeal Vibration (Treatment) for Spasmodic Dysphonia (SD-VTS Trial)

N/A
Waitlist Available
Led By Juergen Konczak, PhD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
diagnosis of adductor SD for a minimum of 6 months with documented symptom relief after botox injection
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up testing performed in lab at week 11
Awards & highlights

SD-VTS Trial Summary

This study is evaluating whether a non-invasive form of neuromodulation can help improve the voice quality of individuals with spasmodic dysphonia.

Eligible Conditions
  • Spasmodic Dysphonia

SD-VTS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

SD-VTS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~testing performed in lab at week 11
This trial's timeline: 3 weeks for screening, Varies for treatment, and testing performed in lab at week 11 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Final Voice Assessment
Voice Assessment During First Visit
Secondary outcome measures
Final Measuring of Cortical Activity Using Electroencephalography (EEG) to Measure Change From Baseline
Measuring of Cortical Activity Using Electroencephalography (EEG) (Baseline)

SD-VTS Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Low-High TreatmentExperimental Treatment1 Intervention
Participants in the low-high treatment group will receive Laryngeal Vibration (Treatment) at 100Hz frequency once a week for a duration of 4 weeks (low intensity). Then they will switch and receive laryngeal vibration at 100Hz frequency every second day of the week (high intensity) for a duration of 4 weeks.
Group II: High-Low TreatmentExperimental Treatment1 Intervention
Participants in the high-low treatment group will receive Laryngeal Vibration (Treatment) at 100Hz frequency every second day of the week for a duration of 4 weeks (high intensity). Then they will switch and receive laryngeal vibration at 100Hz frequency once a week for a duration of 4 weeks (low intensity).
Group III: High-Low ComparatorActive Control1 Intervention
Participants in the high-low comparator group will receive Laryngeal Vibration (Comparator) at 5Hz frequency every second day of the week for a duration of 4 weeks (high intensity). Then they will switch and receive laryngeal vibration at 5Hz frequency once a week for a duration of 4 weeks (low intensity).
Group IV: Low-High ComparatorActive Control1 Intervention
Participants in the low-high comparator group will receive Laryngeal Vibration (Comparator) at 5Hz frequency once a week for a duration of 4 weeks (low intensity). Then they will switch and receive laryngeal vibration at 5Hz frequency every second day of the week (high intensity) for a duration of 4 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Laryngeal Vibration (Treatment)
2019
N/A
~50

Find a Location

Who is running the clinical trial?

National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
328 Previous Clinical Trials
178,263 Total Patients Enrolled
2 Trials studying Spasmodic Dysphonia
193 Patients Enrolled for Spasmodic Dysphonia
University of MinnesotaLead Sponsor
1,378 Previous Clinical Trials
1,588,467 Total Patients Enrolled
2 Trials studying Spasmodic Dysphonia
60 Patients Enrolled for Spasmodic Dysphonia
Juergen Konczak, PhDPrincipal InvestigatorUniversity of Minnesota
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Laryngeal Vibration for Spasmodic Dysphonia
2019. "Laryngeal Vibration for Spasmodic Dysphonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03746509.
~7 spots leftby Apr 2025
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