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Behavioural Intervention

HIV Positive participants for HIV/AIDS

N/A
Waitlist Available
Led By Linda Chang, MD
Research Sponsored by University of Hawaii
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Men or women of any ethnicity, ages>18 years and able to provide informed consent
Stable on an antiretroviral regimen for 6 months or will remain without antiretroviral treatment during the duration of the study.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 month after training, and 6 month after training completion
Awards & highlights

Study Summary

Despite potent combination antiretroviral therapy, cognitive (memory and concentration) problems continue to occur in up to 50% of HIV-infected individuals, especially in older infected individuals, and those who abuse alcohol, marijuana or psychostimulants. Since no effective treatments are available to these individuals with cognitive problems, conservative estimates indicate that the cost of care for these patients could double in the next two decades. To address this urgent problem, this study will use a comprehensive approach (cognitive tests, functional MRI and several biomarkers) to evaluate whether a novel computer-based training program would improve the brain function, especially working memory and attention, in HIV-infected and infected individuals.

Eligible Conditions
  • HIV/AIDS

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 month after training, and 6 month after training completion
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month after training, and 6 month after training completion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Blood-Oxygenation Level-Dependent Functional MRI Measures
Changes in Performances on near transfer working memory tasks
Changes in the Improvement Index on Cogmed™
Secondary outcome measures
Changes in Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A)
Changes in Blood-Oxygenation Level-Dependent Functional MRI Measures based on LMX1A genotypes
Changes in cognitive performance based on LIM homeobox transcription factor 1 alpha (LMX1A) genotypes (AA vs. GA/GG)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Seronegative particpiantsExperimental Treatment2 Interventions
Intervention; 90 seronegative participants will be trained. Half the participants will have the Adaptive WM Cogmed training, and half will have the non-adaptive WM Cogmed training.
Group II: HIV Positive participantsExperimental Treatment2 Interventions
Intervention; 90 HIV positive participants will be trained. Half the participants will have the Adaptive WM Cogmed training, and half will have the non-adaptive WM Cogmed training.

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreOTHER
687 Previous Clinical Trials
374,466 Total Patients Enrolled
University of HawaiiLead Sponsor
115 Previous Clinical Trials
54,509 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,465 Previous Clinical Trials
2,618,453 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Neural Correlates of Working Memory Training for HIV Patients
Linda Chang, M.D. 2012. "Neural Correlates of Working Memory Training for HIV Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02602418.
All > Memory
~14 spots leftby Apr 2025
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