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Procedure

HIV D+/R+ for HIV (Human Immunodeficiency Virus)

N/A

Waitlist Available

Led By Christine Durand, MD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participant is able to understand and provide informed consent

Participant is ≥ 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from transplant through end of follow up (at least 1 year, up to 4 years post-transplant)

Awards & highlights

Study Summary

This trial aims to study rejection in HIV-positive transplant recipients who receive kidneys from donors with or without HIV to improve understanding of the process. "This trial aims to study how rejection occurs in HIV-positive transplant

Who is the study for?

This trial is for adults over 18 with HIV who need a kidney transplant. They must have low levels of HIV in their blood, be generally healthy without significant weight loss from HIV, and meet local transplant criteria. People can't join if they're pregnant, breastfeeding, or have certain serious health issues like brain infections or lymphoma.Check my eligibility

What is being tested?

The study compares the outcomes of kidney transplants in people with HIV receiving kidneys from donors with and without HIV. It aims to understand how donor status affects organ rejection and long-term health after transplantation.See study design

What are the potential side effects?

While specific side effects are not listed here, typical risks associated with kidney transplants may include infection risk due to immunosuppression, possible organ rejection, medication side effects, and complications related to surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I understand the study and can give my consent.

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I am 18 years old or older.

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I am eligible for a kidney transplant according to local guidelines.

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My BMI is 21 or above and I don't have significant weight loss due to HIV.

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My CD4+ T-cell count is 200 or more.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ in the first year post-transplant

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~in the first year post-transplant

This trial's timeline: 3 weeks for screening, Varies for treatment, and in the first year post-transplant for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cumulative incidence of death and allograft rejection.

Secondary outcome measures

Graft function over time measured by eGFR trajectory

Graft survival

Incidence and causes of chronic kidney disease post-transplant

+10 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: HIV D-/R+Experimental Treatment1 Intervention

People living with HIV who receive kidneys from deceased donors without HIV

Group II: HIV D+/R+Experimental Treatment1 Intervention

People living with HIV who receive kidneys from deceased donors with HIV

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute of Allergy and Infectious Diseases (NIAID)NIH

3,269 Previous Clinical Trials

5,481,269 Total Patients Enrolled

Johns Hopkins UniversityLead Sponsor

2,260 Previous Clinical Trials

14,820,580 Total Patients Enrolled

Christine Durand, MDPrincipal InvestigatorJohns Hopkins University

7 Previous Clinical Trials

596 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

At present, how many locations are hosting this particular clinical trial?

"Patients are welcome to participate in this trial at distinguished medical facilities such as Ochsner Clinic Foundation located in New Orleans, Louisiana, University of California, Los Angeles situated in Los Angeles, California and the University of California, San Diego found in San Diego. Additionally, there are 14 other sites available for patient enrollment."

Answered by AI

Are participants currently being recruited for this ongoing medical study?

"The information from clinicaltrials.gov reveals that this particular research is not actively seeking participants. Despite being initially posted on April 1st, 2024 and last updated on February 9th, 2024, it is no longer accepting applicants. However, there are presently 105 alternative trials actively enrolling individuals at the moment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

2024. "Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06263426.

All > Kidney Transplant