← Back to Search

Behavioural Intervention

awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure) for Healthy Subjects

N/A
Waitlist Available
Led By Jie Li, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
healthy adults aged between 21 to 65 years
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 20 minutes
Awards & highlights

Study Summary

This trial will help determine if different respiratory support devices + APP have different effects on ventilation heterogeneity and tidal volumes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~20 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
ventilation distribution assessed by EIT
Secondary outcome measures
comfort
respiratory rates
tidal volume

Trial Design

6Treatment groups
Experimental Treatment
Active Control
Group I: awake prone positioning with high-flow nasal cannulaExperimental Treatment1 Intervention
Participants will stay in the prone position and breathe with high-flow nasal cannula
Group II: awake prone positioning with continuous positive airway pressureExperimental Treatment1 Intervention
Participants will stay in the prone position and breathe with continuous positive airway pressure via face mask
Group III: awake prone positioning with room airActive Control1 Intervention
Participants will stay in the prone position
Group IV: supine position with room airActive Control1 Intervention
Participants will stay in the supine position
Group V: supine position with continuous positive airway pressureActive Control1 Intervention
Participants will stay in the supine position and breathe with continuous positive airway pressure via face mask
Group VI: supine position with high-flow nasal cannulaActive Control1 Intervention
Participants will stay in the supine position and breathe with high-flow nasal cannula

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,511 Total Patients Enrolled
Jie Li, PhDPrincipal InvestigatorRush University
9 Previous Clinical Trials
393 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities to take part in this experiment at present?

"Affirmative. According to clinicaltrials.gov, the trial was first advertised on August 28th 2022 and is still actively recruiting patients. The current goal is to enrol 20 individuals at a single location."

Answered by AI

What type of participants are ideal for this experiment?

"This research requires the inclusion of 20 adults between 21 and 65 years old who are fitted with high flow nasal cannula. The primary criteria for participants is that they must be a healthy member of this age range."

Answered by AI

What is the current size of the participant base for this experiment?

"Yes, clinicaltrials.gov records suggest that this research endeavour is currently recruiting applicants. It was posted on August 28th 2022 and has been updated as of September 1st 2022. Researchers are hoping to include 20 volunteers in the experiment at a single location."

Answered by AI

Does this clinical trial accept participants older than four decades of age?

"This medical trial has an age limit of 21 to 65 years old, with additional 51 trials for minors and 380 studies open to seniors."

Answered by AI
Recent research and studies
Annals of Intensive CareJournal
Awake Prone Position Reduces Work of Breathing in Patients with COVID-19 ARDS Supported by CPAP
Chiumello, Davide, Elena Chiodaroli, Silvia Coppola, Simone Cappio Borlino, Claudia Granata, Matteo Pitimada, and Pedro David Wendel Garcia. 2021. “Awake Prone Position Reduces Work of Breathing in Patients with COVID-19 ARDS Supported by CPAP”. Annals of Intensive Care. Springer Science and Business Media LLC. doi:10.1186/s13613-021-00967-6.
Critical CareJournal
Prone Position Improves Lung Ventilation–perfusion Matching in Non-intubated COVID-19 Patients: A Prospective Physiologic Study
Liu, Ling, Jianfeng Xie, Changsong Wang, Zhanqi Zhao, Yang Chong, Xueyan Yuan, Haibo Qiu, Mingyan Zhao, Yi Yang, and Arthur S. Slutsky. 2022. “Prone Position Improves Lung Ventilation–perfusion Matching in Non-intubated COVID-19 Patients: A Prospective Physiologic Study”. Critical Care. Springer Science and Business Media LLC. doi:10.1186/s13054-022-04069-y.
The Lancet Respiratory MedicineJournal
Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure: A Randomised, Controlled, Multinational, Open-label Meta-trial
Ehrmann, Stephan, Jie Li, Miguel Ibarra-Estrada, Yonatan Perez, Ivan Pavlov, Bairbre McNicholas, Oriol Roca, et al.. 2021. “Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure: A Randomised, Controlled, Multinational, Open-label Meta-trial”. The Lancet Respiratory Medicine. Elsevier BV. doi:10.1016/s2213-2600(21)00356-8.
JamaJournal
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients with Acute Hypoxemic Respiratory Failure and COVID-19
Perkins, Gavin D., Chen Ji, Bronwen A. Connolly, Keith Couper, Ranjit Lall, J. Kenneth Baillie, Judy M. Bradley, et al.. 2022. “Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients with Acute Hypoxemic Respiratory Failure and COVID-19”. Jama. American Medical Association (AMA). doi:10.1001/jama.2022.0028.
~8 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top