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Tailored Regimen for Hemophilia A (PMCH Trial)

N/A

Recruiting

Led By Alfonso Iorio, MD, PhD, FRCPC

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured at study enrollment and at 2 years at study completion.

Awards & highlights

PMCH Trial Summary

This trial will assess the impact of adopting population PK (popPK) based tailored prophylaxis in clinical practice, including proportion of patients eligible for tailoring, and encountered barriers.

Eligible Conditions

Hemophilia A
Hemophilia B

PMCH Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at study enrollment and at 2 years at study completion.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at study enrollment and at 2 years at study completion.

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at study enrollment and at 2 years at study completion. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Annualized Bleeding Rate (ABR) pre and post-tailoring implementation

Change in patient quality of life

Secondary outcome measures

Adherence to prescribed regimen

Assessment of the predictive performance of the WAPPS-Hemo clinical calculator

Change in joint function

+4 more

PMCH Trial Design

1Treatment groups

Experimental Treatment

Group I: Tailored RegimenExperimental Treatment1 Intervention

Implementation of WAPPS-Hemo personalized dosing regimen.

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Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor

880 Previous Clinical Trials

2,597,228 Total Patients Enrolled

2 Trials studying Hemophilia A

1,400 Patients Enrolled for Hemophilia A

Alfonso Iorio, MD, PhD, FRCPCPrincipal InvestigatorMcMaster University

Media Library

WAPPS-Hemo (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03615053 — N/A

WAPPS-Hemo (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03615053 — N/A

Hemophilia A Clinical Trial 2023: WAPPS-Hemo Highlights & Side Effects. Trial Name: NCT03615053 — N/A

Hemophilia A Research Study Groups: Tailored Regimen

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

In which geographical areas is this experiment being implemented?

"This trial is currently running at 8 locations across Canada, the most prominent being University of British Columbia in Vancouver, University of Calgary in Calgary and University of Alberta."

Answered by AI

Has recruitment commenced for this experiment?

"Affirmative. Information hosted on clinicaltrials.gov confirms that the study, which was initially circulated on July 24th 2019, is actively seeking participants. 600 individuals must be enrolled from 6 different medical sites."

Answered by AI

What is the scope of participants taking part in this clinical trial?

"Affirmative, according to data from clinicaltrials.gov this trial is presently recruiting participants. It was first announced on July 24th 2019 and had its most recent update on September 17th 2021. 600 individuals need to be enrolled at 6 various sites for the study's success."

Answered by AI

What is the primary objective of this investigation?

"This research project will be evaluated at intervals of 3-6 months, from enrolment to completion. The primary objective is to assess Annualized Bleeding Rate (ABR) before and after the implementation of tailoring strategies. Secondary objectives include assessing changes in joint function with Hemophilia Joint Health Score (HJHS), tracking adherence to prescribed regimens, and evaluating the predictive performance of WAPPS-Hemo clinical calculator through comparing predicted and observed post-infusion levels."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Personalized Medicine for Canadians With Hemophilia

2019. "Personalized Medicine for Canadians With Hemophilia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03615053.

All > Hemophilia