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Behavioral Intervention

Positive Psychology Intervention for Blood Cancer Survivors (PATH-3 Trial)

N/A
Waitlist Available
Led By Hermioni Amonoo, MD, MPP
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult patients (≥ 18 years) with hematologic malignancies who have received allogeneic HSCT at Dana Farber Cancer Institute who are approaching 100-day post-transplant milestone
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at baseline (registration) and then week 9 (+/- 1 week) and week 18 (+/- 1 week) from the time of registration
Awards & highlights

PATH-3 Trial Summary

This trial is to see if the PATH program is feasible and acceptable to help improve quality of life for those who have undergone stem cell transplant for blood cancer treatment.

Who is the study for?
Adults over 18 who have had a stem cell transplant for blood cancer at Dana Farber Cancer Institute and are nearing their 100-day post-transplant mark. Participants must be able to communicate in English and have access to a phone. Those with cognitive deficits, certain medical conditions, outpatient HSCT, or psychiatric issues that affect compliance are excluded.Check my eligibility
What is being tested?
The trial is testing the PATH program—a positive psychology intervention delivered by phone over nine weeks—to see if it can boost mood, quality of life, and overall health after allogeneic hematopoietic stem cell transplantation.See study design
What are the potential side effects?
Since this is a psychological intervention rather than a drug treatment, traditional physical side effects are not expected. However, participants may experience emotional discomfort when discussing personal topics.

PATH-3 Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am an adult who had a bone marrow transplant at Dana Farber and am nearing 100 days post-transplant.

PATH-3 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at baseline (registration) and then week 9 (+/- 1 week) and week 18 (+/- 1 week) from the time of registration
This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline (registration) and then week 9 (+/- 1 week) and week 18 (+/- 1 week) from the time of registration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acceptability Rate
Feasibility Rate
Secondary outcome measures
Mean Quality of Life Scores
Other outcome measures
Anxiety
Mean Coping Score
Mean Fatigue Score
+12 more

PATH-3 Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PATH InterventionExperimental Treatment1 Intervention
Participants in the PATH Intervention arm will receive psychosocial support phone calls during week 1 through 9 following enrollment. At approximately 100-days post-HSCT, participants will begin an 9-week positive-psychology program involving weekly calls with an interventionist and exercises (i.e. writing a letter of gratitude, identifying personal strengths, planning meaningful and enjoyable activities). -Self-assessment questionnaires to measure positive affect, health behaviors, and overall function before and after completing the Positive Psychology Intervention.
Group II: Usual Care ControlActive Control1 Intervention
Participants in the Usual Care Control arm will receive regular social work assessments as part of HSCT recovery and work does not focus on PPWB skill building or cognitive strategies.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Psychology Intervention
2022
N/A
~90

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,608 Previous Clinical Trials
11,469,807 Total Patients Enrolled
1 Trials studying Blood Cancers
20 Patients Enrolled for Blood Cancers
Dana-Farber Cancer InstituteLead Sponsor
1,078 Previous Clinical Trials
340,802 Total Patients Enrolled
1 Trials studying Blood Cancers
20 Patients Enrolled for Blood Cancers
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,083 Total Patients Enrolled

Media Library

Positive Psychology Intervention (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05147311 — N/A
Blood Cancers Research Study Groups: PATH Intervention, Usual Care Control
Blood Cancers Clinical Trial 2023: Positive Psychology Intervention Highlights & Side Effects. Trial Name: NCT05147311 — N/A
Positive Psychology Intervention (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05147311 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the approximate cohort size for this clinical investigation?

"Indeed, the information hosted on clinicaltrials.gov reveals that this medical trial is actively seeking out patients. It was initially posted to the site on November 17th 2021 and its most recent alteration occurred December 20th 2021. This study requires 70 participants from one single site in order to reach completion."

Answered by AI

Do I qualify to partake in this medical trial?

"To be considered for this clinical trial, applicants must have cancer and range from 18 to 90 years old. Currently, approximately 70 individuals are being admitted into the study."

Answered by AI

Are there any vacancies for individuals in this clinical experiment?

"Data hosted on the clinicaltrials.gov website demonstrates that this medical study is actively recruiting prospective patients, with initial postings occurring on November 17th 2021 and recent updates taking place on December 20th 2021."

Answered by AI

Does this experiment accept enrollees who are over four decades of age?

"This study welcomes any adult aged 18 or over, and up to the age of 90."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Positive Psychology Intervention In HSCT
Hermioni L.Amonoo, MD, MPP 2021. "Positive Psychology Intervention In HSCT". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05147311.
~19 spots leftby Mar 2025
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