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Behavioural Intervention

Best practice alert for the notification of patient HFrEF and recommended evidence-based therapies (NO drugs are being administered in this trial) for Heart Failure (PROMPT-HF Trial)

N/A
Waitlist Available
Led By Tariq Ahmad, MD MPH
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed 6 months post-randomization
Awards & highlights

PROMPT-HF Trial Summary

This trial is testing whether an electronic alert reminding providers about evidence-based medications for heart failure with reduced ejection fraction is more effective than usual care.

Eligible Conditions
  • Heart Failure

PROMPT-HF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed 6 months post-randomization
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed 6 months post-randomization for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Proportion of patients with HFrEF with an increase in prescribed HFrEF therapy
Secondary outcome measures
Medication dose of any prescribed ACEi
Medication dose of any prescribed ARB
Medication dose of any prescribed ARNI
+14 more

PROMPT-HF Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: EHR-based alertExperimental Treatment1 Intervention
Providers will receive a best practice alert for each of their eligible patients upon opening of the order entry screen in the patient's medical record. The alert will inform the provider to the presence of HFrEF and of the patient's current left ventricular ejection fraction and current evidence-based medications for HFrEF. It will also provide access to an order set with recommended evidence-based HFrEF therapies as well as a link to the best available guideline-recommended information regarding the treatment of heart failure.
Group II: Usual CareActive Control1 Intervention
Providers will not receive an alert and will proceed with usual care.

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,852 Previous Clinical Trials
2,738,393 Total Patients Enrolled
32 Trials studying Heart Failure
55,951 Patients Enrolled for Heart Failure
AstraZenecaIndustry Sponsor
4,271 Previous Clinical Trials
288,612,811 Total Patients Enrolled
84 Trials studying Heart Failure
165,978 Patients Enrolled for Heart Failure
Tariq Ahmad, MD MPHPrincipal InvestigatorYale University
2 Previous Clinical Trials
43,124 Total Patients Enrolled
2 Trials studying Heart Failure
43,124 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
American Heart JournalJournal
Rationale and Design of a Cluster-randomized Pragmatic Trial Aimed at Improving Use of Guideline Directed Medical Therapy in Outpatients with Heart Failure: Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure (PROMPT-HF)
Ghazi, Lama, Nihar R. Desai, Michael Simonov, Yu Yamamoto, Kyle D. O'Connor, Ralph J. Riello, Joanna Huang, et al.. 2022. “Rationale and Design of a Cluster-randomized Pragmatic Trial Aimed at Improving Use of Guideline Directed Medical Therapy in Outpatients with Heart Failure: Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure (PROMPT-HF)”. American Heart Journal. Elsevier BV. doi:10.1016/j.ahj.2021.11.010.
American Heart JournalJournal
Rationale and Design of a Cluster-randomized Pragmatic Trial Aimed at Improving Use of Guideline Directed Medical Therapy in Outpatients with Heart Failure: Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure (PROMPT-HF)
Ghazi, Lama, Nihar R. Desai, Michael Simonov, Yu Yamamoto, Kyle D. O'Connor, Ralph J. Riello, Joanna Huang, et al.. 2022. “Rationale and Design of a Cluster-randomized Pragmatic Trial Aimed at Improving Use of Guideline Directed Medical Therapy in Outpatients with Heart Failure: Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure (PROMPT-HF)”. American Heart Journal. Elsevier BV. doi:10.1016/j.ahj.2021.11.010.
Journal of the American College of CardiologyJournal
Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice
Ghazi, Lama, Yu Yamamoto, Ralph J. Riello, Claudia Coronel-Moreno, Melissa Martin, Kyle D. O’Connor, Michael Simonov, et al.. 2022. “Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice”. Journal of the American College of Cardiology. Elsevier BV. doi:10.1016/j.jacc.2022.03.338.
clinicaltrials.govStudy
Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure
2021. "Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04514458.
~11 spots leftby Apr 2025
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