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Behavioural Intervention

Cognitive Training for Heart Failure (SYNAPSE Trial)

N/A

Recruiting

Led By Louis Bherer, PhD

Research Sponsored by Louis Bherer

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult aged 50 or older

Without limitation of physical activity to severe limitation of physical activity (i.e. NYHA class I, class II, class III OR class IV)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up before and after the 6 weeks of interventions

Awards & highlights

SYNAPSE Trial Summary

This trial will study the effects of a cognitive training program on heart-failure patients' cognitive functions.

Who is the study for?

This trial is for adults aged 50 or older with chronic heart failure who can use the internet and a computer or tablet. They should be able to do cognitive exercises and understand consent forms. People with severe physical limitations, recent acute cardiovascular events, upcoming heart procedures, uncontrolled diabetes, untreated thyroid issues, short-term cancer prognosis, neurological diseases, or on dialysis cannot join.Check my eligibility

What is being tested?

The SYNAPSE trial is testing if a home-based cognitive training program improves thinking skills in patients with heart failure compared to usual care without this program. Participants will either receive the special training or continue their normal routine.See study design

What are the potential side effects?

Since this study involves cognitive exercises rather than medication, traditional side effects are not expected. However, participants may experience fatigue or frustration during mental tasks.

SYNAPSE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 50 years old or older.

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My heart condition does not severely limit my physical activity.

SYNAPSE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before and after the 6 weeks of interventions

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before and after the 6 weeks of interventions

This trial's timeline: 3 weeks for screening, Varies for treatment, and before and after the 6 weeks of interventions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in performance on trained computerized cognitive tasks

Changes in performance on transfer computerized cognitive tasks

Secondary outcome measures

Change in general cognitive functioning

Change in quality of life

Change in self-care behavior

+1 more

Other outcome measures

Change in Risk of sleep apnea

Change in Walking test speed

Change in anxiety

+10 more

SYNAPSE Trial Design

2Treatment groups

Experimental Treatment

Group I: Usual care followed by cognitive trainingExperimental Treatment2 Interventions

Usual care (only) for 6 weeks, followed by cognitive training and usual care for 6 weeks.

Group II: Cognitive training followed by usual careExperimental Treatment2 Interventions

Usual care and cognitive training for 6 weeks, followed by usual care (only) for 6 weeks.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Louis BhererLead Sponsor

5 Previous Clinical Trials

377 Total Patients Enrolled

The Montreal Health Innovations Coordinating Center (MHICC)OTHER

13 Previous Clinical Trials

10,832 Total Patients Enrolled

3 Trials studying Heart Failure

482 Patients Enrolled for Heart Failure

Louis Bherer, PhDPrincipal InvestigatorMontreal Heart Institute

8 Previous Clinical Trials

737 Total Patients Enrolled

1 Trials studying Heart Failure

216 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available vacancies in this clinical experiment?

"As per information posted on clinicaltrials.gov, this medical research study is not presently seeking potential participants; it was first published on February 21st 2022 and last edited one month later. Nevertheless, there are 702 other studies actively searching for volunteers right now."

Answered by AI

What benefits are researchers hoping to bring about with this research endeavor?

"The primary aim of this six-week trial is to assess the changes in performance on computerized cognitive tests. Secondary objectives include alterations in neuropsychological scores evaluated through remote versions of validated tasks such as Trail Making Test B, Verbal Fluency Test and Digit Span Test; modifications to quality of life reflected by SF-36 (an index ranging from 0-100 with higher values indicating better health status); plus fluctuations in self-care behaviour recorded using EHFsB-9 (a scale which goes from 9 up to 45 with a higher score representing less active patient care)."

Answered by AI

Recent research and studies

American Heart JournalJournal

Cognitive Influences on Self-care Decision Making in Persons with Heart Failure

Dickson, Victoria V., Nancy Tkacs, and Barbara Riegel. 2007. “Cognitive Influences on Self-care Decision Making in Persons with Heart Failure”. American Heart Journal. Elsevier BV. doi:10.1016/j.ahj.2007.04.058.

Frontiers in Human NeuroscienceJournal

An Investigation of Response and Stimulus Modality Transfer Effects After Dual-task Training in Younger and Older

Lussier, Maxime, Christine Gagnon, and Louis Bherer. 2012. “An Investigation of Response and Stimulus Modality Transfer Effects After Dual-task Training in Younger and Older”. Frontiers in Human Neuroscience. Frontiers Media SA. doi:10.3389/fnhum.2012.00129.

StrokeJournal

Telephone Assessment of Cognition After Transient Ischemic Attack and Stroke

Pendlebury, Sarah T., Sarah J.V. Welch, Fiona C. Cuthbertson, Jose Mariz, Ziyah Mehta, and Peter M. Rothwell. 2013. “Telephone Assessment of Cognition After Transient Ischemic Attack and Stroke”. Stroke. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/strokeaha.112.673384.

Journal of the American Heart AssociationJournal