Transcranial Magnetic Stimulation for Hormonal Modulation in Healthy Women

KD
Overseen ByKyle Donnery, M.S
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research is to establish whether non-invasive Transcranial Magnetic Stimulation (TMS), can affect modulation of hormones such: Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH).

The hypothesis is that applying TMS to the Dorsolateral Prefrontal Cortex with specific pulse patterns, mimicking endogenous Gonodotropin-Releasing Hormone (GnRH) pulses that are known to stimulate LH secretion may modulate hormonal levels.

Who Is on the Research Team?

MB

Marom Bikson, PhD

Principal Investigator

The City College of New York

Are You a Good Fit for This Trial?

This trial is for healthy women aged 22-40 with regular menstrual cycles, specifically in the luteal phase at the time of their visit. It's not suitable for those who don't meet these specific age and menstrual cycle criteria.

Inclusion Criteria

I am currently in the luteal phase of my menstrual cycle.
I am a healthy woman aged 22-40 with regular menstrual cycles.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive Transcranial Magnetic Stimulation (TMS) or sham intervention to assess hormonal modulation

1 day
1 visit (in-person)

Follow-up

Participants are monitored for changes in serum LH and FSH levels and affect post-intervention

1 day
6 blood draws during the visit

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation

Trial Overview

The study tests if Transcranial Magnetic Stimulation (TMS) can influence hormone levels like Luteinizing Hormone (LH) when applied to a part of the brain called the Dorsolateral Prefrontal Cortex using special pulse patterns.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: ActiveActive Control1 Intervention
Group II: ShamPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The City College of New York

Lead Sponsor

Trials
32
Recruited
6,700+