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Hyperpolarized Xenon MRI for Healthy Volunteers

HS
TL
Overseen ByTommy Li, Msc
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Alexei Ouriadov
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Healthy volunteers aged 18 to 85 will undergo hyperpolarized Xenon-129 (¹²⁹Xe) MRI and pulmonary function testing. The study aims to develop evaluation tools for ventilation defect percent (VDP), signal-to-noise and contrast-to-noise ratios (SNR/CNR) of ¹²⁹Xe dissolved-phase images, and spectroscopy-based analysis.

Are You a Good Fit for This Trial?

Inclusion Criteria

Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature
Provision of written, informed consent prior to any study specific procedures
I am between 18 and 85 years old.
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Exclusion Criteria

In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI or CT, such as severe claustrophobia
Participant is unable to perform spirometry maneuvers
Patient has an MR incompatible implanted mechanically, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) (at the discretion of the MRI Technologist)
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What Are the Treatments Tested in This Trial?

Interventions

  • Hyperpolarized Xenon MRI

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Hyperpolarized Xenon MRIExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Alexei Ouriadov

Lead Sponsor

St. Joseph's Health Care London

Collaborator

Trials
28
Recruited
2,500+

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