15 Participants Needed

Functional MRI Study on Food Intake Regulation in Healthy Subjects

MS
Overseen ByMegan Schaefer
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.

Will I have to stop taking my current medications?

If you are taking any medication or supplement that alters appetite, you will need to stop taking it to participate in this study.

Is the use of functional MRI to study food intake regulation safe for humans?

Functional MRI (fMRI) is a non-invasive imaging technique used to study brain activity and has been widely used in research to understand how the brain responds to food and appetite-related processes. It is generally considered safe for humans, as it does not involve exposure to radiation.12345

How does this treatment differ from other treatments for food intake regulation?

This treatment is unique because it uses functional MRI (fMRI) to study how the brain regulates food intake by examining brain activity related to taste, aroma, and food cravings. Unlike other treatments that might focus on diet or medication, this approach provides insights into the brain's role in appetite and food-related behaviors.12367

What data supports the effectiveness of the treatment Hedonic Meal in regulating food intake?

Functional MRI studies have shown that the brain's response to food involves complex pathways related to pleasure and reward, which are influenced by hormones like ghrelin and peptide YY. These insights suggest that treatments focusing on the pleasurable aspects of eating, like a Hedonic Meal, could potentially modulate food intake by engaging these reward-related brain regions.12389

Who Is on the Research Team?

AA

Andres Acosta

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for healthy adults with a BMI of 18-25, stable weight for the past 3 months, and able to do light to moderate exercise. Women must be in the first half of their menstrual cycle. Exclusions include MRI contraindications, obesity history, claustrophobia, high-intensity athletes, intragastric balloon issues, food allergies or eating disorders, substance abuse including tobacco/alcohol use, psychiatric conditions or significant medical comorbidities.

Inclusion Criteria

Weight stable for 3 months prior to study entry
BMI 18-25 kg/m^2
Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures
See 2 more

Exclusion Criteria

Any history of psychiatric disorders
Pregnancy or nursing
Any allergies to the study meals
See 11 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo functional MRI after caloric and volumetric stimulus to study hormonal and neural responses

4 weeks
Multiple visits for MRI and hormone level assessments

Follow-up

Participants are monitored for changes in caloric consumption, hormone levels, and cerebral blood flow

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Hedonic Meal
Trial Overview The study examines how gut hormones and brain responses differ when presented with gastric distention from an intragastric balloon versus tasteless calories versus enjoyable food using functional MRI scans to see how these factors affect hunger and appetite.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Food-Print Main ArmExperimental Treatment4 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Published Research Related to This Trial

Functional neuroimaging techniques like PET and fMRI have begun to reveal how the human brain responds to hunger, taste, and fullness, providing insights into the neurophysiological mechanisms behind eating behaviors.
Studies show that there are distinct differences in brain function between obese and lean individuals, highlighting the complexity of obesity and suggesting that neuroimaging could be crucial for understanding and treating eating disorders.
Functional neuroimaging: a new generation of human brain studies in obesity research.Tataranni, PA., DelParigi, A.[2019]
Functional MRI (fMRI) has advanced our understanding of how the brain integrates sensory inputs related to food, revealing how taste, aroma, and fat are processed in relation to appetite and food pleasantness.
Recent studies using fMRI have shown that hormonal influences, such as peptide YY and ghrelin, significantly affect brain responses related to appetite, highlighting the complex regulatory mechanisms behind food intake.
Imaging methodologies and applications for nutrition research: what can functional MRI offer?Francis, ST., Eldeghaidy, S.[2015]
Recent advances in neuroimaging techniques like fMRI and PET have allowed researchers to study how food influences brain reward systems, revealing that both hedonistic and homeostatic drives affect eating behavior.
Hormones such as leptin, peptide YY3-36, and ghrelin play significant roles in modulating brain activity related to food rewards, which could inform the development of new treatments for obesity and eating disorders.
Gaining new insights into food reward with functional neuroimaging.Neary, MT., Batterham, RL.[2021]

Citations

Functional neuroimaging: a new generation of human brain studies in obesity research. [2019]
Imaging methodologies and applications for nutrition research: what can functional MRI offer? [2015]
Gaining new insights into food reward with functional neuroimaging. [2021]
Brain activity in hunger and satiety: an exploratory visually stimulated FMRI study. [2008]
Cortical and limbic activation during viewing of high- versus low-calorie foods. [2019]
Brain regions implicated in inhibitory control and appetite regulation are activated in response to food portion size and energy density in children. [2018]
Neuroimaging the interaction of mind and metabolism in humans. [2023]
Brain-based etiology of weight regulation. [2022]
Images of desire: food-craving activation during fMRI. [2013]
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