Functional MRI Study on Food Intake Regulation in Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Will I have to stop taking my current medications?
If you are taking any medication or supplement that alters appetite, you will need to stop taking it to participate in this study.
Is the use of functional MRI to study food intake regulation safe for humans?
How does this treatment differ from other treatments for food intake regulation?
This treatment is unique because it uses functional MRI (fMRI) to study how the brain regulates food intake by examining brain activity related to taste, aroma, and food cravings. Unlike other treatments that might focus on diet or medication, this approach provides insights into the brain's role in appetite and food-related behaviors.12367
What data supports the effectiveness of the treatment Hedonic Meal in regulating food intake?
Functional MRI studies have shown that the brain's response to food involves complex pathways related to pleasure and reward, which are influenced by hormones like ghrelin and peptide YY. These insights suggest that treatments focusing on the pleasurable aspects of eating, like a Hedonic Meal, could potentially modulate food intake by engaging these reward-related brain regions.12389
Who Is on the Research Team?
Andres Acosta
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for healthy adults with a BMI of 18-25, stable weight for the past 3 months, and able to do light to moderate exercise. Women must be in the first half of their menstrual cycle. Exclusions include MRI contraindications, obesity history, claustrophobia, high-intensity athletes, intragastric balloon issues, food allergies or eating disorders, substance abuse including tobacco/alcohol use, psychiatric conditions or significant medical comorbidities.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo functional MRI after caloric and volumetric stimulus to study hormonal and neural responses
Follow-up
Participants are monitored for changes in caloric consumption, hormone levels, and cerebral blood flow
What Are the Treatments Tested in This Trial?
Interventions
- Hedonic Meal
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor