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Functional MRI Study on Food Intake Regulation in Healthy Subjects

N/A

Recruiting

Led By Andres Acosta, MD, PhD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 month

Awards & highlights

Study Summary

This trial will study how the brain and gut respond to tasteless calories, distention, or palatable food, and how this affects appetite.

Who is the study for?

This trial is for healthy adults with a BMI of 18-25, stable weight for the past 3 months, and able to do light to moderate exercise. Women must be in the first half of their menstrual cycle. Exclusions include MRI contraindications, obesity history, claustrophobia, high-intensity athletes, intragastric balloon issues, food allergies or eating disorders, substance abuse including tobacco/alcohol use, psychiatric conditions or significant medical comorbidities.Check my eligibility

What is being tested?

The study examines how gut hormones and brain responses differ when presented with gastric distention from an intragastric balloon versus tasteless calories versus enjoyable food using functional MRI scans to see how these factors affect hunger and appetite.See study design

What are the potential side effects?

Potential side effects may include discomfort from the intragastric balloon procedure or reactions related to consuming study meals if unknown allergies exist. The MRI scan could cause unease in those with claustrophobia but generally has no significant side effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 month

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 month

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Difference in Cerebral Blood Flow related to hypothalamus

Secondary outcome measures

Caloric consumption differences in stimuli

Cerebral Blood Flow between three stimuli

Brain

+6 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Food-Print Main ArmExperimental Treatment4 Interventions

Functional Magnetic Resonance Imaging (pCASL-MRI) after Caloric and Volumetric stimulus in lean patients will be performed on all patients in the study

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,216 Previous Clinical Trials

3,767,473 Total Patients Enrolled

Andres Acosta, MD, PhDPrincipal InvestigatorMayo Clinic

2 Previous Clinical Trials

116 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

May I participate in this medical experiment?

"This clinical trial seeks 15 healthy participants aged between 21 and 50. Further, applicants must possess a BMI of 18-25 kg/m^2., have maintained steady weight for 3 months prior to the study beginning, be able to give written informed consent before any procedures are conducted, demonstrate aptitude in moderate physical activity, and if female – participate during their follicular phase (the initial 13 days)."

Answered by AI

What are the primary aims of this clinical research endeavor?

"The main metric under observation during this month-long clinical trial is the Primary Endpoint. Complementary measurements include temporal variations to meals after maximal fullness, cerebral blood flow discrepancies between three distinct stimuli, and physical activity assessed by a FitBit tracker while living freely."

Answered by AI

Does the population for this trial encompass individuals aged over sixty?

"This clinical trial seeks out participants who are younger than 50 and above the age of majority."

Answered by AI

What is the upper limit of individual participants in this clinical research?

"Indeed, the clinicaltrials.gov website reveals that this medical trial is actively enrolling participants. Since its initial posting on September 8th 2022 and last update October 11th 2022, 15 individuals will be accepted from a single centre."

Answered by AI

Does the research team have room for new participants?

"According to the pertinent information on clinicaltrials.gov, this trial is in an open recruitment period and has been since September 8th 2022 after its most recent update on October 11th of that year."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

Andres J. Acosta, M.D., Ph.D. 2022. "Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05525845.