Temporal Interference for Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition. In the short term, the investigators aim to validate and characterize the effects of TI on brain activity as measured by fMRI and demonstrate its ability to focally stimulate deep brain regions without affecting overlying cortex. In the longer term, investigators aim to use these data to resolve longstanding debates about the function of deeper brain regions and lay the foundation for future clinical applications of TI for treating addiction, Obsessive-Compulsive Disorder (OCD), Parkinson's disease, and other disorders involving deep brain dysfunction. The grant supports 2 distinct aims, each of which will be evaluated through a series of independent studies.
Who Is on the Research Team?
Joshua W Brown, PhD
Principal Investigator
Indiana University, Bloomington
Are You a Good Fit for This Trial?
This trial is for healthy individuals aged 18 to 50 who have completed at least a sixth-grade education and are proficient in English. Specific details on who cannot participate were not provided.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive temporal interference (TI) electrical stimulation targeting the nucleus accumbens during a single study visit
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Temporal Interference (TI) Electrical Stimulation
Trial Overview
The study tests Temporal Interference (TI) electrical stimulation, aiming to stimulate deep brain regions without affecting the cortex. It involves comparing active TI at different frequencies (5 Hz and 10 Hz) with sham (placebo) treatments using fMRI measurements.
How Is the Trial Designed?
4
Treatment groups
Active Control
Participants in this arm receive temporal interference (TI) electrical stimulation targeting the nucleus accumbens using two pairs of carbon fiber electrodes in the following order: 5 Hz TI Active, 5 Hz TI Sham, 10 Hz TI Active, then 10 Hz TI Sham.
Participants in this arm receive temporal interference (TI) electrical stimulation targeting the nucleus accumbens using two pairs of carbon fiber electrodes in the following order: 5 Hz TI Sham, 5 Hz TI Active, 10 Hz TI Sham, then 10 Hz TI Active.
Participants in this arm receive temporal interference (TI) electrical stimulation targeting the nucleus accumbens using two pairs of carbon fiber electrodes in the following order: 10 Hz TI Sham, 10 Hz TI Active, 5 Hz TI Sham, then 5 Hz TI Active.
Participants in this arm receive temporal interference (TI) electrical stimulation targeting the nucleus accumbens using two pairs of carbon fiber electrodes in the following order: 10 Hz TI Active, 10 Hz TI Sham, 5 Hz TI Active, then 5 Hz TI Sham.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Indiana University
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator
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