High Added Sugar Meal for Healthy Aging

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Delaware, Newark, DE
Healthy Aging+1 More
High Added Sugar Meal - Other
Eligibility
18 - 65
All Sexes
What conditions do you have?
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Study Summary

This study will focus on acute effects of added sugars on brain health in a specific age group (30-64 years old). We will provide participants two meals (one meal containing 16 g of added sugars and the other containing 61 g of added sugars) and examine blood vessel function and brain structure using a MRI.

Eligible Conditions

  • Healthy Aging
  • Healthy Diet

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

6 Primary · 4 Secondary · Reporting Duration: Over 2 weeks, at baseline and 3 hours post-consumption of each meal (low and high added sugar), separated by a 1-week washout

Week 2
Change from baseline in blood pressure at 3 hours post-consumption of each meal
Change from baseline in cerebrovascular reactivity at 3 hours post-consumption of each meal
Change from baseline in hippocampal cerebrovascular reactivity at 3 hours post-consumption of each meal
Change from baseline in hippocampal damping ratio at 3 hours post-consumption of each meal
Change from baseline in hippocampal stiffness after 3 hours post-consumption of each meal
Change from baseline in other lipid profile at 3 hours post-consumption of each meal
Change from baseline in oxidative stress at 3 hours post-consumption of each meal
Change from baseline in triglycerides at 3 hours post-consumption of each meal
Change from baseline in uric acid at 3 hours post-consumption of each meal
Changes from baseline in resting cerebral blood flow at 3 hours post-consumption of each meal

Trial Safety

Trial Design

2 Treatment Groups

Low Added Sugar Meal
1 of 2
High Added Sugar Meal
1 of 2
Experimental Treatment

20 Total Participants · 2 Treatment Groups

Primary Treatment: High Added Sugar Meal · No Placebo Group · N/A

Low Added Sugar Meal
Other
Experimental Group · 1 Intervention: Low Added Sugar Meal · Intervention Types: Other
High Added Sugar Meal
Other
Experimental Group · 1 Intervention: High Added Sugar Meal · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: over 2 weeks, at baseline and 3 hours post-consumption of each meal (low and high added sugar), separated by a 1-week washout
Closest Location: University of Delaware · Newark, DE
Photo of delaware 1Photo of delaware 2Photo of delaware 3
2007First Recorded Clinical Trial
2 TrialsResearching Healthy Aging
43 CompletedClinical Trials

Who is running the clinical trial?

University of DelawareLead Sponsor
130 Previous Clinical Trials
36,430 Total Patients Enrolled
1 Trials studying Healthy Aging
40 Patients Enrolled for Healthy Aging
Christopher Martens, PhDStudy DirectorUniversity of Delaware

Eligibility Criteria

Age 18 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You do not have any allergies or intolerances to ingredients in the study meal.
You are eligible for the study if you are between the ages of 30-64 years and are either male or female.
You have a habit of consuming added sugar in excess of the recommended amount.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.