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Optical Spectroscopy for Head and Neck Cancer

N/A

Waitlist Available

Led By Moreno Mauricio, MD

Research Sponsored by University of Arkansas

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 years and older

Scheduled for chemoradiation therapy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 weeks

Awards & highlights

Study Summary

This trial will test the ability of two cancer-detecting methods, diffuse reflectance spectroscopy (DRS) and Raman spectroscopy (RS), to work together to accurately identify cancer in patients with head and neck squamous cell carcinoma (HNSCC).

Who is the study for?

This trial is for adults with Stage 3 or 4 head and neck squamous cell carcinoma (HNSCC) in the larynx or one tonsil. Participants must be scheduled for chemoradiation, able to undergo a laryngoscope procedure, and have documented HPV status. Pregnant or breastfeeding women, those with previous related surgeries, or disease in both tonsils cannot join.Check my eligibility

What is being tested?

The study tests how well diffuse reflectance spectroscopy (DRS) and Raman spectroscopy (RS) can identify treatment-resistant cancer by measuring changes in oxygenation and molecules in oral cavity tumors during treatment.See study design

What are the potential side effects?

Since this trial involves diagnostic procedures rather than drugs, side effects are minimal but may include discomfort from the laryngoscope procedure used to perform DRS and RS.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I am scheduled for combined chemotherapy and radiation treatment.

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My cancer is in my tonsil or larynx.

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I have stage 3 or 4 head and neck cancer, and know if it's related to HPV.

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I can undergo a laryngoscope procedure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Successful identification of treatment-resistant disease

Trial Design

1Treatment groups

Experimental Treatment

Group I: Use of Optical SpectroscopyExperimental Treatment1 Intervention

Optical spectroscopy used to characterize treatment response

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Optical Spectroscopy

2008

N/A

~40

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of ArkansasLead Sponsor

486 Previous Clinical Trials

150,263 Total Patients Enrolled

Moreno Mauricio, MDPrincipal InvestigatorUniversity of Arkansas

Media Library

Optical Spectroscopy (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04272294 — N/A

Head and Neck Cancers Research Study Groups: Use of Optical Spectroscopy

Head and Neck Cancers Clinical Trial 2023: Optical Spectroscopy Highlights & Side Effects. Trial Name: NCT04272294 — N/A

Optical Spectroscopy (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04272294 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research project currently recruiting volunteers?

"According to the information hosted on clinicaltrials.gov, this trial is no longer actively recruiting participants; though it was initially posted March 1st 2023 and last updated in March 14th 2022. Currently, there are 480 other medical trials looking for enrolment from volunteers across the United States of America."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Functional and Molecular Characterization of Treatment Response in Tumors in the Oral Cavity Using Optical Spectroscopy

2024. "Functional and Molecular Characterization of Treatment Response in Tumors in the Oral Cavity Using Optical Spectroscopy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04272294.