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Radiation

Quad Shot Radiation Therapy for Head and Neck Cancer (PEAQ-RT Trial)

N/A

Waitlist Available

Led By Wade Thorstad, M.D.

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up completion of treatment by all patients enrolled (estimated to be 3 years and 12 weeks)

Awards & highlights

PEAQ-RT Trial Summary

This trial is testing whether a new way of delivering radiation for palliative care is feasible.

Eligible Conditions

Head and Neck Cancer

PEAQ-RT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ completion of treatment by all patients enrolled (estimated to be 3 years and 12 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~completion of treatment by all patients enrolled (estimated to be 3 years and 12 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and completion of treatment by all patients enrolled (estimated to be 3 years and 12 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Feasibility as measured by the successful completion of Quad shot radiation using CBCT instead of routine CT simulation in 80% of attempted simulated patients

Secondary outcome measures

Average time (days) required from initial consult to completion of radiation therapy for patient travel and visits to the department

Percentage of patients from whom repeat CT simulation was eliminated

PEAQ-RT Trial Design

1Treatment groups

Experimental Treatment

Group I: Quad shot radiationExperimental Treatment2 Interventions

-Radiotherapy will consist of Quad shot radiation delivered on the Ethos ring gantry kV-CBCT combined with linear accelerator system to a dose of 14 Gy in four, twice-daily fractions of 3.5 Gy delivered at least 6 hours apart over two days for a possible total of 3 cycles delivered in 3 to 4 intervals for a cumulative dose of of 42 Gy in 12 fractions. Cycle 2 and 3 of treatment is not mandated per protocol but may be given at the discretion of the treating physician.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Quad shot radiation

2020

N/A

~10

Ring gantry kV-CBCT combined with linear accelerator (Halcyon)

2020

N/A

~10

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Who is running the clinical trial?

Washington University School of MedicineLead Sponsor

1,933 Previous Clinical Trials

2,299,715 Total Patients Enrolled

Varian Medical SystemsIndustry Sponsor

58 Previous Clinical Trials

3,729 Total Patients Enrolled

Wade Thorstad, M.D.Principal InvestigatorWashington University School of Medicine

1 Previous Clinical Trials

27 Total Patients Enrolled

Media Library

Quad shot radiation (Radiation) Clinical Trial Eligibility Overview. Trial Name: NCT04379505 — N/A

Head and Neck Cancers Research Study Groups: Quad shot radiation

Head and Neck Cancers Clinical Trial 2023: Quad shot radiation Highlights & Side Effects. Trial Name: NCT04379505 — N/A

Quad shot radiation (Radiation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04379505 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any more places available to participate in this clinical experiment?

"As per the information on clinicaltrials.gov, this medical trial is open for enrolment and has been since October 1st 2020. The data was last modified on November 10th 2022."

Answered by AI

How many participants are taking part in this experiment?

"That is accurate. According to clinicaltrials.gov, this medical trial has been open since October 1st 2020 and currently recruiting participants with its last update on November 10th 2022. It looks for enrolment of up to 10 patients at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Palliative Expeditiously Adaptive Quad Shot Radiation Therapy (PEAQ-RT)

2020. "Palliative Expeditiously Adaptive Quad Shot Radiation Therapy (PEAQ-RT)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04379505.