CLINICAL TRIAL

Treatment for Glaucoma, Open-Angle

Recruiting · 18+ · All Sexes · Philadelphia, PA

This study is evaluating whether a medical food may help improve vision for individuals with glaucoma.

See full description

About the trial for Glaucoma, Open-Angle

Eligible Conditions
Glaucoma, Open-Angle · Glaucoma · Ocular Hypertension, Primary Open-angle Glaucoma (POAG)

Treatment Groups

This trial involves 4 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Control Group 1
Placebo
OTHER
Control Group 2
GlaucoCetin
DIETARYSUPPLEMENT
Control Group 3
GlaucoCetin
DIETARYSUPPLEMENT
Show More

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Group 1 has a defect that meets the HPA criteria, but does not meet the criteria for Group 2. show original
At least one eye has bilateral open angle glaucoma and reliable visual field defects, with the mean deviation being between -4.00 and -10.00 decibels. show original
apart The pressure inside the eye is controlled using two measurements that are more than three months apart from each other. show original
The age range of 40 to 80 years is when most people are considered to be in their middle years show original
Group 2 (Central): has at least one paracentral point that is repeatedly depressed at a rate of less than 1% on tests performed on February 24th show original
You have normal vision if you have 20/40 vision or better in each eye. show original
Clear media
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 20 minute questionnaires during a 6 month period
Screening: ~3 weeks
Treatment: Varies
Reporting: 20 minute questionnaires during a 6 month period
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 20 minute questionnaires during a 6 month period.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome and 2 secondary outcomes in patients with Glaucoma, Open-Angle. Measurement will happen over the course of 3 hour examinations during a 6 month period.

Visual Field Mean Deviation
3 HOUR EXAMINATIONS DURING A 6 MONTH PERIOD
Improvement in visual field mean deviation, measured in decibels, will be compared before, during and after a 6 month trial of daily GlaucoCetin vs Placebo capsules.
3 HOUR EXAMINATIONS DURING A 6 MONTH PERIOD
Perceived Quality of Life Improvement measured by National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25)
20 MINUTE QUESTIONNAIRES DURING A 6 MONTH PERIOD
Improvement in participants perceived vision-related quality of life ( National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25))
20 MINUTE QUESTIONNAIRES DURING A 6 MONTH PERIOD
Perceived Quality of Life Improvement
20 MINUTE QUESTIONNAIRES DURING A 6 MONTH PERIOD
Improvement in participants perceived vision-related quality of life (GQL-15, Glaucoma Symptom Scale (GSS)
20 MINUTE QUESTIONNAIRES DURING A 6 MONTH PERIOD

Who is running the study

Principal Investigator
N. N. K.
Natasha Nayak Kolomeyer, MD
Wills Eye

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for glaucoma, open-angle?

Glaucoma has a complex etiology and many treatment types are used to help prevent the progression of the eye. The most common treatment is eye medication. Topical alpha blockers decrease the intraocular pressure (IOP).

Anonymous Patient Answer

What is glaucoma, open-angle?

Glaucoma, open-angle is a health condition that impedes vision and reduces quality of life; approximately one in 10 adults may be affected. Glaucoma, open-angle occurs when an eye or optic nerve has increased pressure which causes damage to the optic nerve, nerve fiber and the retina. The retina's function has been compromised by which causes a decrease in the person's ability to detect things correctly, perceive objects and the ability to distinguish colors. Glaucoma, open-angle is a condition that may not cause serious issues, but with a high mortality rate is very devastating for the person who is affected, and may eventually result in blindness.

Anonymous Patient Answer

Can glaucoma, open-angle be cured?

A careful assessment of the disease at the beginning of treatment can help avoid the need to switch from topical to an inferior glaucoma surgery and prevent recurrent glaucoma. Glaucoma can be eradicated in many patients if the disease isn't too advanced, if they have the right treatment and if they follow the treatment long enough before switching over to surgery. All these things are possible with the right diagnosis.

Anonymous Patient Answer

How many people get glaucoma, open-angle a year in the United States?

One in seven people in the U.S. have glaucoma every year; this is less than other regions but highlights the need for nationwide screening programs. When tested with a more targeted questionnaire, nearly two thirds of new cases in this age group are missed. More than a quarter of the newly diagnosed glaucoma patients have glaucoma and are under-diagnosed.

Anonymous Patient Answer

What are the signs of glaucoma, open-angle?

The two most frequent signs of open-angle glaucoma are an increased intraocular pressure and decreased visual acuity. The only reliable way to distinguish between open-angle glaucoma and ocular hypertension is by checking the visual field in close or near with an automated perimetry such as HRT II or the test for HCT.

Anonymous Patient Answer

What causes glaucoma, open-angle?

Glaucoma, open-angle appears to exist at a threshold of pressure to which the aqueous disc may burst. The degree of IOP rise appears to be related to the rate of pressure change, the extent of increased IOP, and the underlying cause of the increase in IOP.\n

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

When treating primary open-angle glaucoma, both single and combination treatments are typically used. The combination treatments of topical agents and laser may be one of the most common treatments. In primary angle closure glaucoma, topical agents are used more frequently due to the potential of worsening angle closure.

Anonymous Patient Answer

What does treatment usually treat?

About one out of two patients can expect [to have a treatment effect on several patient-reported measures after treatment.] However, when the data were pooled across several study arms, over one-half of patients still fail to experience a clinically important treatment benefit on at least one of the measures examined. Although patients experience a significant reduction in pain when treated, it generally does not improve general health status. Even assuming that treatment-related improvement is significant in half of patients, these data suggest that a significant number of patients do not benefit from conventional glaucoma treatment.

Anonymous Patient Answer

Does glaucoma, open-angle run in families?

Data from a recent study confirms evidence supporting the concept that glaucoma, open angle runs in some families and supports a linkage of this disease to region 5q25.2 (located at chr5q25.2). This chromosomal region was noted to overlap with an earlier reported linkage of optic disc drusiom to chr17q in this region.

Anonymous Patient Answer

Have there been any new discoveries for treating glaucoma, open-angle?

No new therapies have been established for the treatment of glaucoma. Recent findings of many studies have supported the use of glaucoma medication for various people. However, many patients do not respond to their treatment, and most patients still use medication inappropriately.

Anonymous Patient Answer

What is the latest research for glaucoma, open-angle?

The research is still in the initial stages, but this is where we should start. We are excited for the possibility that some new, effective treatments will be developed in the near future.

Anonymous Patient Answer

What are the latest developments in treatment for therapeutic use?

Despite advances in the therapeutics used in the management of glaucoma, the treatments that were available are still not the ideal. There are some promising developments in adjuvant and complementary treatments which aim at further reducing the risk of glaucoma progression and increasing the survival rates of patients. There has also been a significant effort to provide more effective treatment options for people living with advanced stages of glaucoma.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Glaucoma, Open-Angle by sharing your contact details with the study coordinator.