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Proton Pump Inhibitor

Esomeprazole for Non-erosive Reflux Disease

N/A
Waitlist Available
Led By Prateek Sharma, M.D.
Research Sponsored by Midwest Biomedical Research Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Capable of giving informed consents.
Cases of NERD will be recruited on the basis of presence of heartburn and/or regurgitation using two validated GERD questionnaires in conjunction with an abnormal esophageal pH result and absence of erosions at standard endoscopy.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 weeks
Awards & highlights

Study Summary

This trial is testing a new way to diagnose non-acid reflux disease, which is difficult to confirm without a gold standard. The blue light endoscopy technique may help improve diagnosis of the condition.

Eligible Conditions
  • Non-erosive Reflux Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
NBI endoscopy identifies changes in the distal esophagus that are specific for diagnosing patients with Non-Esophageal Reflux Disease.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: EsomeprazoleActive Control1 Intervention
proton pump inhibitor
Group II: PlaceboPlacebo Group1 Intervention
placebo

Find a Location

Who is running the clinical trial?

Midwest Biomedical Research FoundationLead Sponsor
25 Previous Clinical Trials
9,220 Total Patients Enrolled
Kansas City Veteran Affairs Medical CenterFED
23 Previous Clinical Trials
8,470 Total Patients Enrolled
Prateek Sharma, M.D.Principal InvestigatorVA Office of Research and Development
1 Previous Clinical Trials
13 Total Patients Enrolled

Frequently Asked Questions

~6 spots leftby Mar 2025