Anti-reflux mucosal ablation (ARAT) for Acid Reflux

Phase-Based Progress Estimates
Kansas City VA Hospital, Kansas City, MOAcid RefluxARAT - Procedure
18 - 80
All Sexes
What conditions do you have?

Study Summary

This trial will examine if the ARAT is an effective and safe treatment for patients with chronic GERD symptoms.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: At 3, 6 and 12 months

Month 12
Beta-Aminoethylisothiuronium Dihydrobromide
Change in Hiatal hernia grading
Esophagitis incidence
Month 12
Change in GERD health related quality of life (GERD-HRQL) score
Change in Proton pump inhibitor (PPI) use
Change in Reflux disease questionnaire (RDQ) score
Day 30
Adverse events

Trial Safety

Trial Design

2 Treatment Groups

Anti-reflux mucosal ablation (ARAT)
1 of 2
No treatment
1 of 2

Active Control

Non-Treatment Group

36 Total Participants · 2 Treatment Groups

Primary Treatment: Anti-reflux mucosal ablation (ARAT) · Has Placebo Group · N/A

No treatment
ShamComparator Group · 1 Intervention: Sham intervention (control) · Intervention Types: Procedure
Anti-reflux mucosal ablation (ARAT)
ActiveComparator Group · 1 Intervention: ARAT · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: at 3, 6 and 12 months

Who is running the clinical trial?

Midwest Veterans' Biomedical Research FoundationLead Sponsor
Prateek Sharma, MDPrincipal InvestigatorKansas City VA Hospital
18 Previous Clinical Trials
8,765 Total Patients Enrolled
Madhav Desai, MDStudy DirectorKansas City VA Hospital

Eligibility Criteria

Age 18 - 80 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have experienced heartburn or acid reflux at least twice a week for the past 6 months.

Frequently Asked Questions

Is the eligibility for this examination restricted to individuals of a certain age?

"This medical study is currently welcoming participants aged 18 to 80." - Anonymous Online Contributor

Unverified Answer

Who qualifies to participate in this research?

"To be eligible for entry, potential participants must have gastroesophageal reflux and fit within the 18 to 80 age range. As of now, 36 patients are needed for this clinical trial." - Anonymous Online Contributor

Unverified Answer

Are participants still being recruited for this research endeavor?

"The information available on verifies that recruitment events are taking place for this study. It was initially posted in mid-February and edited most recently during early October of 2022." - Anonymous Online Contributor

Unverified Answer

How many participants have been recruited for this clinical experiment?

"Affirmative. According to, this trial is currently seeking volunteers for participation; it was initially posted on February 15th 2022 and the most recent update occurred October 5th of the same year. The study intends to enroll 36 patients from a single medical centre." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.