Optical Coherence Tomography for Fuchs' Dystrophy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial uses a special imaging technology called optical coherence tomography (OCT) to study how corneal swelling affects vision in people with Fuchs' endothelial dystrophy, an eye condition that causes blurry vision. The research aims to predict how vision changes after surgical treatment by observing corneal swelling. People with corneal problems due to Fuchs' dystrophy who haven't had major eye surgery (except for simple cataract surgery) might be a good fit for this study. As an unphased trial, this study offers participants the opportunity to contribute to groundbreaking research that could improve future treatment strategies for Fuchs' dystrophy.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What prior data suggests that optical coherence tomography is safe for observing Fuchs' dystrophy?
Research has shown that Optical Coherence Tomography (OCT) is a safe technology for taking detailed pictures of the eye without invasive procedures. Studies have found that OCT allows doctors to see the layers of the eye, particularly in conditions like Fuchs' dystrophy, without harming patients. As a non-invasive method, OCT avoids surgery or direct contact with the eye, reducing the risk of side effects. No major reports of problems related to OCT have emerged, and patients generally tolerate it well.12345
Why are researchers excited about this trial?
Researchers are excited about using Optical Coherence Tomography (OCT) for Fuchs' Dystrophy because it offers a non-invasive and highly detailed way to look at the layers of the cornea, which is a major improvement over traditional methods like slit-lamp exams. Unlike standard treatments that focus on managing symptoms or require surgical intervention, OCT can provide precise imaging that helps in monitoring the progression of the disease more effectively. This technique could lead to earlier and more accurate diagnoses, potentially guiding better treatment decisions and improving patient outcomes.
What evidence suggests that optical coherence tomography is effective for Fuchs' dystrophy?
Research has shown that optical coherence tomography (OCT) serves as a valuable tool for examining Fuchs' endothelial dystrophy. It captures detailed images of the eye's tissues, enabling doctors to clearly view the cornea's structure. This detailed perspective is crucial for monitoring corneal swelling and assessing changes post-surgery. While OCT is not a treatment, it aids doctors in understanding the disease's impact on the eye. By providing clear images, OCT helps predict corneal changes, guiding treatment decisions for improved outcomes.25678
Who Is on the Research Team?
Winston Chamberlain, MD, PhD
Principal Investigator
Oregon Health and Science University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observation
Participants undergo optical coherence tomography (OCT) to quantify corneal edema and predict refractive shift
Follow-up
Participants are monitored for safety and effectiveness after observation
What Are the Treatments Tested in This Trial?
Interventions
- Observational Study
- Optical Coherence Tomography (OCT)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Oregon Health and Science University
Lead Sponsor
National Eye Institute (NEI)
Collaborator