1110 Participants Needed

Ready. Set. Food! for Preventing Food Allergies

(EASE Trial)

PS
Overseen ByParth Shah, MD
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Prollergy dba Ready Set Food
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether participants must stop taking their current medications. However, it does exclude infants with certain medical conditions or those on chronic antibiotics, which might suggest some restrictions.

What data supports the effectiveness of the treatment Ready. Set. Food! for preventing food allergies?

The research suggests that early introduction of potential allergens, like peanuts, into an infant's diet can help prevent food allergies, which aligns with the approach of Ready. Set. Food! in preventing food allergies.12345

How is the treatment Ready. Set. Food! different from other treatments for preventing food allergies?

Ready. Set. Food! is unique because it focuses on early exposure to allergenic foods in infants' diets as a strategy to prevent food allergies, which is different from the traditional approach of avoiding allergenic foods. This method aims to reduce the risk of developing allergies by introducing small amounts of potential allergens early on, rather than eliminating them from the diet.26789

What is the purpose of this trial?

Multiple clinical trials have demonstrated that early allergen introduction, feeding babies common food allergens before six months, decreases children's risk of developing a food allergy. Despite successful food allergy introduction trials showing that food allergies can be prevented, early introduction in the required amount can be challenging for parents. In some studies, less than 20% of parents introduce peanuts before their child is six months old, and few feed them regularly after introduction. Ready. Set. Food! is a direct-to-consumer product that offers a convenient supplement with a daily dose regimen that can be added to breastmilk, formula, or food to make early allergen introduction easy. The formulation includes cow's milk, egg, and peanut, representing the majority of childhood food allergies, and the protein levels are based on doses found to be effective in clinical trials. Over 200,000 infants have used Ready. Set. Food!.This study investigates the effectiveness of introducing common allergens to infants with the goal of preventing food allergies. The study will enroll 1,100 infants stratified by their risk of developing a food allergy who are assigned to either receive Ready. Set. Food! supplements or follow standard allergen introduction practices recommended by their pediatrician.The goal of this study is to assess how Ready. Set. Food! allergen introduction supplements improve the experience of parents introducing allergens, decrease healthcare costs related to food allergies, and decrease food allergy prevalence.

Research Team

VG

Vikram Garg, MD

Principal Investigator

Curavit

KM

Kara McNamara, MD

Principal Investigator

ObvioHealth

Eligibility Criteria

This trial is for caregivers of full-term, single-birth infants aged 2-5 months who are willing to use a smartphone app and follow study guidelines. It's aimed at those who can consent to the study's requirements and live with the infant throughout the trial. Infants at risk of developing food allergies may be included.

Inclusion Criteria

I have given birth to one baby at full term.
I am the caregiver or legal guardian of the infant.
I will be living with the infant throughout the study.
See 5 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive an early allergen introduction supplement or follow standard practices

6 months
No in-person visits, real-world environment

Follow-up

Participants are monitored for adverse events and adherence to allergen introduction

18 months

Treatment Details

Interventions

  • Ready. Set. Food!
Trial Overview The trial tests 'Ready. Set. Food!' supplements, which contain cow's milk, egg, and peanut proteins for early allergen introduction in infants versus standard practices advised by pediatricians. The goal is to see if these supplements make it easier for parents and reduce both healthcare costs and allergy rates.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: InterventionExperimental Treatment1 Intervention
Participants randomized to the intervention group will receive an early allergen introduction supplement.
Group II: ControlActive Control1 Intervention
Participants randomized to the control group will follow the guidance of their pediatrician.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Prollergy dba Ready Set Food

Lead Sponsor

Trials
1
Recruited
1,100+

ObvioHealth

Industry Sponsor

Trials
12
Recruited
11,200+

References

Primary Prevention of Food Allergy. [2020]
Dietary management of food allergy. [2019]
[Actual status of children with food allergies and food provision at residential nurseries and children's care homes: Comparison of groups using and not using guidelines or manuals]. [2019]
Current concepts: diagnosis and management of food allergy in children. [2018]
5.Bosnia and Herzegovinapubmed.ncbi.nlm.nih.gov
Peanut Allergy - No Longer a Life Sentence. [2021]
Nip allergies in the Bub: a qualitative study for a public health approach to infant feeding for allergy prevention. [2022]
Early Exposure to Cow's Milk Protein Is Associated with a Reduced Risk of Cow's Milk Allergic Outcomes. [2020]
Patient-Centered Outcomes in Food Allergy. [2018]
Primary dietary prevention of food allergy. [2006]
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