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Sugar drink for Non-alcoholic Fatty Liver Disease

N/A

Waitlist Available

Led By Saroja Voruganti

Research Sponsored by University of North Carolina, Chapel Hill

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0, 1 and 3 hours at week 0 and week 3

Awards & highlights

Study Summary

This trial will help researchers learn more about how different people respond to fructose and how it affects their risk for developing NAFLD.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0, 1 and 3 hours at week 0 and week 3

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0, 1 and 3 hours at week 0 and week 3

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 1 and 3 hours at week 0 and week 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Liver fat content (%)

Serum concentrations of low density lipoprotein-triglycerides (VLDL-TG)

Secondary outcome measures

Serum concentrations of HDL cholesterol

Serum concentrations of LDL cholesterol

Serum concentrations of liver function marker (Alanine transaminase- ALT).

+6 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Low GRS groupExperimental Treatment1 Intervention

This groups consists of individuals who are in the lowest quartile of the genetic risk score (GRS) and will ingest one sugar drink (equal to 2 soft drinks) per day for 3 weeks. The GRS is computed by adding the number of alleles that increase the risk for liver lipogenesis or fatty liver.

Group II: High GRS groupExperimental Treatment1 Intervention

This group consists of individuals who are in the highest quartile of the genetic risk score (GRS) and will ingest one sugar drink (equal to 2 soft drinks) per day for 3 weeks. The GRS is computed by adding the number of alleles that increase the risk for liver lipogenesis or fatty liver.

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Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor

1,501 Previous Clinical Trials

4,186,697 Total Patients Enrolled

2 Trials studying Non-alcoholic Fatty Liver Disease

31 Patients Enrolled for Non-alcoholic Fatty Liver Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,352 Previous Clinical Trials

4,315,127 Total Patients Enrolled

47 Trials studying Non-alcoholic Fatty Liver Disease

9,972 Patients Enrolled for Non-alcoholic Fatty Liver Disease

Saroja VorugantiPrincipal InvestigatorUniversity of North Carolina, Chapel Hill

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants is this study accommodating?

"Correct. Information found on clinicaltrials.gov affirms that this medical trial is still in the recruitment stage, having been first posted on January 25th 2019 and last updated March 25th 2022. 48 participants are needed to be sourced from a single location."

Answered by AI

Is the enrollment period open for this experiment?

"Affirmative. Per the information hosted on clinicaltrials.gov, this experiment is actively searching for patients to participate in its research as of March 25th 2022; it was initially posted on January 25th 2019 and requires 48 volunteers from a single site."

Answered by AI

What is the goal of this medical investigation?

"This clinical trial's primary goal is to measure the variation of very low density lipoprotein-triglycerides (VLDL-TG) production rate over a 3 week interval. Secondary objectives encompass tracking changes in serum concentrations of HDL cholesterol, total cholesterol, and triglycerides through fasting measurements."

Answered by AI

Who is an ideal candidate for this medical research?

"To be considered for participation in this trial, potential candidates must have a form of liver disease and fall between the ages 12 to 40. This clinical study is actively seeking 48 participants."

Answered by AI

Is the age limit for participating in this research project restricted to individuals 25 and under?

"For this specific medical study, the age range is circumscribed between 12 and 40 years old. Contrastingly, 36 trials are recruiting patients younger than 18 while 333 studies seek to recruit participants who are over 65."

Answered by AI