185 Participants Needed

Effort Valuation for Fatigue

AG
Overseen ByAnthony Gonzalez
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Research Team

VS

Vikram S. Chib, PhD

Principal Investigator

Kennedy Krieger Institute and Johns Hopkins School of Medicine

Eligibility Criteria

This trial is for right-handed individuals aged between 18 and 35, of any gender or ethnicity. It's not suitable for those who are pregnant, have metal in their head/eyes, neurological issues like stroke or epilepsy, severe claustrophobia during MRI scans, excessive tattoo heating from MRIs, or a history of severe psychiatric conditions.

Inclusion Criteria

You use your right hand more often than your left hand.
People of any race can participate.

Exclusion Criteria

If they are pregnant or suspect that you may be pregnant
You have metal in your head or eyes.
You have experienced neurological problems in the past such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, or Parkinson's Disease.
See 3 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Cognitive Fatigue Induction

Participants perform a cognitively demanding task repeatedly to induce cognitive fatigue

1 day
1 visit (in-person)

Physical Fatigue Induction

Participants perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue

1 day
1 visit (in-person)

Motivational State Modulation

Participants' motivational state is modulated using reward-associated stimuli to study effort choices

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after interventions

1-2 weeks

Treatment Details

Interventions

  • Cognitive Fatigue
  • Physical Fatigue
  • Rewarding Stimuli
Trial Overview The study aims to understand how the brain values effort when tired or motivated. Participants will undergo tests related to cognitive and physical fatigue as well as exposure to rewarding stimuli while their brain activity is monitored.
Participant Groups
3Treatment groups
Experimental Treatment
Group I: Rewarding StimuliExperimental Treatment1 Intervention
We will use a behavioral intervention. Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.
Group II: Physical FatigueExperimental Treatment1 Intervention
We will use a behavioral intervention. Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.
Group III: Cognitive FatigueExperimental Treatment1 Intervention
We will use a behavioral intervention. Participants will perform a cognitively demanding task, repeatedly, to induce cognitive fatigue.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Lead Sponsor

Trials
93
Recruited
25,200+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+
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