Effort Valuation for Fatigue
Trial Summary
What is the purpose of this trial?
The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.
Research Team
Vikram S. Chib, PhD
Principal Investigator
Kennedy Krieger Institute and Johns Hopkins School of Medicine
Eligibility Criteria
This trial is for right-handed individuals aged between 18 and 35, of any gender or ethnicity. It's not suitable for those who are pregnant, have metal in their head/eyes, neurological issues like stroke or epilepsy, severe claustrophobia during MRI scans, excessive tattoo heating from MRIs, or a history of severe psychiatric conditions.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Cognitive Fatigue Induction
Participants perform a cognitively demanding task repeatedly to induce cognitive fatigue
Physical Fatigue Induction
Participants perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue
Motivational State Modulation
Participants' motivational state is modulated using reward-associated stimuli to study effort choices
Follow-up
Participants are monitored for safety and effectiveness after interventions
Treatment Details
Interventions
- Cognitive Fatigue
- Physical Fatigue
- Rewarding Stimuli
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator