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Cognitive Fatigue for Fatigue

N/A

Recruiting

Led By Vikram S. Chib, PhD

Research Sponsored by Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 day

Awards & highlights

Study Summary

This trial will study how the brain values effort, and how this changes when a person is tired or motivated.

Who is the study for?

This trial is for right-handed individuals aged between 18 and 35, of any gender or ethnicity. It's not suitable for those who are pregnant, have metal in their head/eyes, neurological issues like stroke or epilepsy, severe claustrophobia during MRI scans, excessive tattoo heating from MRIs, or a history of severe psychiatric conditions.Check my eligibility

What is being tested?

The study aims to understand how the brain values effort when tired or motivated. Participants will undergo tests related to cognitive and physical fatigue as well as exposure to rewarding stimuli while their brain activity is monitored.See study design

What are the potential side effects?

There may be no direct side effects from the interventions since they involve non-invasive procedures like MRI scans and behavioral tasks. However, participants might experience discomfort due to fatigue tasks or anxiety in an MRI machine.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Difference between cognitive effort cost parameters between the low and high reward stimuli

Difference between physical effort cost parameters between the low and high reward stimuli

Differences between cognitive subjective effort parameters before and after fatigue (from behavioral choice data)

+9 more

Trial Design

3Treatment groups

Experimental Treatment

Group I: Rewarding StimuliExperimental Treatment1 Intervention

We will use a behavioral intervention. Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.

Group II: Physical FatigueExperimental Treatment1 Intervention

We will use a behavioral intervention. Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.

Group III: Cognitive FatigueExperimental Treatment1 Intervention

We will use a behavioral intervention. Participants will perform a cognitively demanding task, repeatedly, to induce cognitive fatigue.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Physical Fatigue

2019

N/A

~40

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH

2,784 Previous Clinical Trials

2,689,090 Total Patients Enrolled

4 Trials studying Fatigue

375 Patients Enrolled for Fatigue

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.Lead Sponsor

88 Previous Clinical Trials

24,753 Total Patients Enrolled

Vikram S. Chib, PhDPrincipal InvestigatorKennedy Krieger Institute and Johns Hopkins School of Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor accept participants who are over two decades of age?

"This medical trial requires that participants are within the 18 to 35 age range. Concurrently, 12 studies are enrolling minors and 169 trials accommodate patients beyond 65 years old."

Answered by AI

Is it still feasible to participate in this clinical investigation?

"Affirmative, the information provided on clinicaltrials.gov indicates that this trial is currently endeavoring to enroll participants. This research was initially posted on August 1st 2018 and was last altered on November 28th 2022; 185 individuals are being sought at a single site."

Answered by AI

To what demographics is enrollment in this clinical trial available?

"This medical study will be enrolling 185 test subjects aged between 18 and 35 years old who are experiencing fatigue. To participate, applicants must meet the following additional criteria: gender (male or female), ethnicity (any), handedness (right)."

Answered by AI

How many individuals are currently participating in this research experiment?

"Indeed, the information posted on clinicaltrials.gov conveys that this research is in search of participants. The trial was initially published on August 1st 2018 and has since been updated as recently as November 28th 2022. This medical study seeks 185 enrollees from a solitary location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Behavioral and Neural Representations of Subjective Effort Cost

Vikram Chib 2018. "Behavioral and Neural Representations of Subjective Effort Cost". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04041154.