Meal Order for Abnormal Glucose Metabolism
What You Need to Know Before You Apply
What is the purpose of this trial?
Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are using insulin, you would not be eligible to participate.
Is changing the order of food consumption in meals safe for humans?
Research suggests that changing the order of food consumption in meals, such as eating protein and vegetables before carbohydrates, is generally safe for humans. However, consuming a low-carbohydrate meal in the evening may increase triglyceride levels, which could raise the risk of arteriosclerosis (hardening of the arteries).12345
How does the carbohydrate-first or carbohydrate-last meal treatment differ from other treatments for abnormal glucose metabolism?
This treatment is unique because it focuses on the order in which foods are consumed during a meal, specifically eating carbohydrates either first or last. This approach can influence blood sugar levels by delaying the digestion of carbohydrates and enhancing insulin release, which is different from traditional treatments that might focus on medication or overall dietary changes.12367
What data supports the effectiveness of the carbohydrate-first and carbohydrate-last meal order treatment for abnormal glucose metabolism?
Are You a Good Fit for This Trial?
This trial is for individuals with conditions like abnormal glucose metabolism, diabetes, or liver metabolic disorders. It's also relevant for those interested in how food order affects blood sugar and fuel use during rest. Participants should be comfortable with consuming vegetarian meals as part of the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume meals with different food orders to assess impact on blood glucose and fuel utilization
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Carbohydrate-first meal
- Carbohydrate-last meal
Find a Clinic Near You
Who Is Running the Clinical Trial?
Old Dominion University
Lead Sponsor