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Intermittent Fasting for Sports Injuries

N/A

Waitlist Available

Research Sponsored by Indiana University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

At least three years of soccer heading experience

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up mri procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading).

Awards & highlights

Study Summary

This trial will study the effect of fasting on the brain's response to minor head injuries sustained while playing soccer. Blood tests, MRI scans, and eye exams will be used to measure the impact of the injuries and the effect of fasting on the brain.

Eligible Conditions

Sports Injuries
Intermittent Fasting

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

You have played soccer and headed the ball for at least three years.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ mri procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading).

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~mri procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading).

This trial's timeline: 3 weeks for screening, Varies for treatment, and mri procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in a panel of metabolites from day 4 to day 5 and group differences

Change in a panel of metabolites from day 4 to day 7 and group differences

Change in axonal microstructure from day 4 to day 5 and group differences

+7 more

Secondary outcome measures

Change in King Devick performance from day 0 to day 4 and group differences

Change in King Devick performance from day 4 to day 7 and group differences

Change in brain-derived blood biomarkers from day 0 to day 4 and group differences

+4 more

Trial Design

5Treatment groups

Experimental Treatment

Active Control

Group I: Pre-heading fastedExperimental Treatment1 Intervention

Pre-Heading Fasted Group: Individuals randomly assigned to undergo a 20 hour fast with a 4 hour eating window for a 5-day period prior to the soccer heading.

Group II: Post-heading fastedExperimental Treatment1 Intervention

Post-Heading Fasted Group: Individuals randomly assigned to undergo a 20 hour fast with a four hour eating window for a 3-day period following the soccer heading.

Group III: FastedExperimental Treatment1 Intervention

Fasted Group: Individuals randomly assigned to undergo a 20 hour fast with a four hour eating window for the entire 8-day period of the study.

Group IV: ControlExperimental Treatment1 Intervention

Control Group: Individuals randomly assigned to eat per usual over the course of the entire 8-day study period.

Group V: Subconcussive Head ImpactActive Control1 Intervention

All four groups undergo the same soccer heading model as described below. Device: Soccer Heading Soccer Heading: Subjects stood approximately 40 feet away from a JUGS soccer ball launcher and participated in 20 consecutive soccer headings, separated by 30 second intervals.

0 / 1Eligibility criteria met