CLINICAL TRIAL

Intermittent Fasting for Sports Injuries

Recruiting · 18 - 65 · All Sexes · Bloomington, IN

The Effect of Intermittent Fasting on Acute Subconcussive Head Impacts

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About the trial for Sports Injuries

Eligible Conditions
Sports Injuries · Fasting, Intermittent · Athletic Injuries

Treatment Groups

This trial involves 5 different treatments. Intermittent Fasting is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
Intermittent Fasting
PROCEDURE
Experimental Group 2
Intermittent Fasting
PROCEDURE
Experimental Group 3
Intermittent Fasting
PROCEDURE
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About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intermittent Fasting
2016
N/A
~360

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 2 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
18-30 years of age
You have played soccer for at least three years. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: MRI procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading).
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: MRI procedures will be performed day 4 (prior to heading) and day 7 (72 hours post-heading)..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Intermittent Fasting will improve 10 primary outcomes and 7 secondary outcomes in patients with Sports Injuries. Measurement will happen over the course of Near point of convergence will be assessed at day 0 and day 4 (prior to heading)..

Change in near point of convergence from day 0 to day 4 and group differences
NEAR POINT OF CONVERGENCE WILL BE ASSESSED AT DAY 0 AND DAY 4 (PRIOR TO HEADING).
Participants will undergo a brief test of near-point of convergence
Change in King Devick performance from day 0 to day 4 and group differences
KING DEVICK PERFORMANCE WILL BE ASSESSED AT DAY 0 AND DAY 4 (PRIOR TO HEADING)
Participants will undergo the King-Devick Test--a brief assessment of saccadic eye movements, attention, and visual and language processing
Change in brain-derived blood biomarkers from day 0 to day 4 and group differences
BLOOD SAMPLES WILL BE COLLECTED AT DAY 0 AND DAY 4 (PRIOR TO HEADING).
Blood samples will be collected and centrifuged at 1500 x g for ten minutes at 4 degree celsius. Serum samples will be aliquoted and stored at -80 degree celsius until analysis. Serum samples will be assayed for neurofilament-light (NfL) and glial fibrillary acidic protein (GFAP). All expression levels in pg/mL.
Change in brain-derived blood biomarkers from day day 0 to day 5 and group differences
BLOOD SAMPLES WILL BE COLLECTED AT DAY 0 AND DAY 5 (24 HOURS POST HEADING).
Blood samples will be collected and centrifuged at 1500 x g for ten minutes at 4 degree celsius. Serum samples will be aliquoted and stored at -80 degree celsius until analysis. Serum samples will be assayed for neurofilament-light (NfL) and glial fibrillary acidic protein (GFAP). All expression levels in pg/mL.
Change in brain-derived blood biomarkers from day day 0 to day 7 and group differences
BLOOD SAMPLES WILL BE COLLECTED AT DAY 0 AND DAY 7 (72 HOURS POST HEADING).
Blood samples will be collected and centrifuged at 1500 x g for ten minutes at 4 degree celsius. Serum samples will be aliquoted and stored at -80 degree celsius until analysis. Serum samples will be assayed for neurofilament-light (NfL) and glial fibrillary acidic protein (GFAP). All expression levels in pg/mL.
Change in regional fMRI activation during the memory task from day 4 to day 5 and group differences
FMRI PROCEDURES WILL BE PERFORMED ON DAY 4 (PRIOR TO HEADING) AND DAY 5 (24 HOURS POST-HEADING)
A standardized MRI protocol acquired on a Siemens TIM Trio scanner, equipped with a 64 channel phased array head radiofrequency coil will be used to collect fMRI images while a working memory task is administered. The task based fMRI protocol consists of N-back verbal working memory and a resting state task.
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Who is running the study

Principal Investigator
K. K.
Prof. Keisuke Kawata, Assistant Professor Kinesiology
Indiana University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get fasting, intermittent a year in the United States?

During the last three decades fasting, especially intermittent fasting, has become a widely used method of intermittent short-term calorie control, with an increasing number of publications on the benefits of intermittent fasting and of fasting, intermittent and the possible therapeutic implications of such a paradigm in many diseases, including diabetes type 2. A total number of 14,621 people per year in the U.S. were documented with fasting, intermittent or intermittent and intermittent dietary changes. This number increased by 25% in the last 20 years. Based on these data, it cannot help but to emphasize the great number of people involved in alternative food and weight control.

Anonymous Patient Answer

What is fasting, intermittent?

Fasting, intermittent may reduce the risk of diabetes. It has been an optional health advice for people who prefer to reduce weight and body fat, and has also been recommended by medical bodies in several countries; there is strong evidence for this recommendation in general. Fasting, intermittent may be a promising option for lifestyle modification in preventing diabetes.

Anonymous Patient Answer

Can fasting, intermittent be cured?

Fasting has a significant anti-inflammatory effect, but intermittent fasting will not. Findings from a recent study highlights that both fasting and in-between intermittent fasting are effective and safe in the management of GI inflammation. It can be considered a first-line therapy for the treatment of GI inflammation.

Anonymous Patient Answer

What are the signs of fasting, intermittent?

A significant change in energy balance and metabolic parameters occurred in subjects who fasted and when food was provided. The changes in the fasting subjects were greater than those in a control group. These changes were also greater in patients who fasted intermittently compared with a normal weight group. Because of the high prevalence of obesity and hypertriglyceridemia in patients with type 2 diabetes mellitus, these data suggest that fasting as a form of therapy may be a useful intervention in treatment of patients who have type 2 diabetes mellitus and fasting.

Anonymous Patient Answer

What causes fasting, intermittent?

Fasting interrupts the homeostatic drive to ingest to remove unneeded food, in combination with intermittent exposure to suboptimal levels of oxygen. This inducible hypoxic response leads to an increase in unneeded food intake at the expense of oxygen transport and delivery.

Anonymous Patient Answer

What are common treatments for fasting, intermittent?

Fasting has a myriad of potential benefits as an adjunct treatment for weight management in cancer patients though additional evidence is required. The intermittent fasting technique of periodic fasting may be a non-invasive avenue to investigate in the control of cancer related metabolic risk in clinical settings. The short term safety and efficacy of intermittent fasting has not been established. A prospective clinical study is required to explore this technique as an adjunct to calorie restriction for weight management in this population.

Anonymous Patient Answer

What is the average age someone gets fasting, intermittent?

Fasting intermittent is a safe way to lose weight, without negatively affecting your health in the long run. The average is 19.8 years, based off a sample of 583 people.

Anonymous Patient Answer

How serious can fasting, intermittent be?

Fasting, intermittent improves endurance performance. Whether such fasting can provide the same benefits as a habitual exercise regime is an issue still poorly elucidated for intermittent fasting.

Anonymous Patient Answer

What does intermittent fasting usually treat?

There was no convincing evidence of benefit of IF for treating non-diabetic people with high levels of blood glucose, with or without risk factors, and in both groups with [type 2 diabetes](https://www.withpower.com/clinical-trials/type-2-diabetes). There was no convincing evidence for improved lipid profiles or reduction in the occurrence of microalbuminuria in either group after randomizations, suggesting that the observed differences in fasting metabolic parameters were unimportant in people with diabetes. There was little or no evidence that IF is effective in treating any of any symptoms, parameters, or outcomes, or in improving lifestyle factors in both groups. There was no convincing evidence for safety in those with type 2 diabetes. All findings are consistent with the conclusion that IF had no beneficial effect on the outcomes evaluated in this study.

Anonymous Patient Answer

What is intermittent fasting?

Intermittent fasts are a new approach to diet management, wherein the caloric intake is restricted to four to five hours per day (depending on the meal schedule of the individual). The calorie intake is limited during the fasted state and then replenished afterwards. In this manner, the fasting state can be maintained indefinitely, without regard to any subsequent caloric intake. In contrast with long-term fasting, intermittent fasting does not alter overall energy balance and does not lead to weight gain. Intermittent fasting has proven to be beneficial in treating a number of diseases such as metabolic syndrome and type 2 diabetes. In some cases intermittent fasting is necessary to avoid serious health complications. Such problems have prompted interest among scientists and clinicians working to determine optimal intermittent fasting patterns.

Anonymous Patient Answer

What is the primary cause of fasting, intermittent?

The frequent use of the word fasting to describe intermittent fasting in the medical literature and literature specifically for people with diabetes and prediabetes may have misleading effects because fasting can occur in non-diabetic individuals. As suggested by the literature, intermittent fasting can be an effective approach to achieving and maintaining a healthy blood glucose level in prediabetics who do not go through a period of unrestricted food consumption before undertaking an intermittent fast.

Anonymous Patient Answer

What are the latest developments in intermittent fasting for therapeutic use?

Findings indicate that fasting is a useful and novel therapeutic approach for the treatment of several indications and indications to which traditional therapies have limitation. It may help patients in the control of the occurrence of many chronic diseases (for example diabetes mellitus, hypertension, dyslipidemia, obesity) associated with the lack of adherence of the therapeutic regimen.

Anonymous Patient Answer
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