Your session is about to expire
← Back to Search
VQ vs. CT Scans for Preventing Acute Kidney Injury (VQ/CT Trial)
N/A
Recruiting
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age≥18 years
CTPA ordered by the treating provider to evaluate PE
Timeline
Screening 3 weeks
Treatment Varies
Follow Up >/= 48 hours to </= 168 hours of enrollment
Awards & highlights
VQ/CT Trial Summary
This trial is studying whether using a VQ scan instead of a CT scan to look for pulmonary embolism can help prevent kidney problems in patients.
Who is the study for?
This trial is for adults who might have a pulmonary embolism but are at low risk (≤20% chance) and have a moderate to high risk of developing kidney problems from IV dye (CINRisk Score ≥2). It's not for those with recent or upcoming contrast exposure, history of certain lung conditions, pregnancy, active dialysis, renal transplant, or clinical instability.Check my eligibility
What is being tested?
The study compares two imaging tests: CT scans that use IV dye and V/Q scans that don't. The goal is to see if the V/Q scan can prevent contrast-induced kidney damage in patients needing evaluation for possible pulmonary embolism.See study design
What are the potential side effects?
CT scan side effects may include allergic reactions to the dye leading to kidney issues known as CIN which often has no symptoms but requires blood tests. V/Q scans generally do not involve these risks as they use different substances.
VQ/CT Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
My doctor has ordered a CT scan to check for blood clots in my lungs.
VQ/CT Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ >/= 48 hours to </= 168 hours of enrollment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~>/= 48 hours to </= 168 hours of enrollment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Acute kidney injury in subjects exposed and unexposed to iodinated contrast media
Secondary outcome measures
Validate the acute kidney injury score, alone and in combination with acute-phase markers of renal dysfunction.
VQ/CT Trial Design
3Treatment groups
Active Control
Group I: Randomized to V/QActive Control1 Intervention
300 patients with > 25% estimated risk of CIN (CINRisk Score ≥ 2), randomized to VQ imaging (unexposed control)
Group II: Low risk for kidney injury with use of CTActive Control1 Intervention
No randomization due to low risk for kidney injury. 100 patients undergoing CTPA with an estimated risk of CIN <10% (CINRisk Score <2)
Group III: Randomized to CTActive Control1 Intervention
300 patients with > 25% estimated risk of CIN (CINRisk Score ≥ 2), randomized to CT (exposure to iodinated contrast media)
Find a Location
Who is running the clinical trial?
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,837 Previous Clinical Trials
47,850,927 Total Patients Enrolled
19 Trials studying Pulmonary Embolism
149,055 Patients Enrolled for Pulmonary Embolism
Indiana UniversityLead Sponsor
980 Previous Clinical Trials
982,576 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- The likelihood of having a pulmonary embolism (PE) is less than 20%.Your risk of getting contrast-induced nephropathy (CIN) from the imaging procedure is high, at 25% or more.I haven't had dye for imaging tests in the last 14 days and don't plan to in the next 7 days.I am 18 years old or older.Only patients with a low CINRisk Score will be included in the study. They will get a CT scan as recommended by their doctor, not by chance. Researchers will use the data from these low-risk patients, as well as high-risk patients who get a CT scan by chance, to check how well the CINRisk Score works.I am too unwell for certain lung scans.I have been on dialysis or planned to start it within the last 30 days.My doctor has ordered a CT scan to check for blood clots in my lungs.I have had lung surgery or signs of lung issues on an X-ray.You have had a kidney transplant in the past or plan to have one within 30 days of joining the study.You are pregnant or have given birth within the past 48 hours.
Research Study Groups:
This trial has the following groups:- Group 1: Randomized to V/Q
- Group 2: Low risk for kidney injury with use of CT
- Group 3: Randomized to CT
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger