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Fluid Replacement

Pentastarch Use in Cardiac Surgery

N/A
Waitlist Available
Led By Irene Cybulsky, MD
Research Sponsored by Hamilton Health Sciences Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All patients undergoing either coronary artery bypass surgery or valve surgery requiring the use of cardiopulmonary bypass circuit
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is testing whether using Pentaspan during surgery impacts a patient's recovery.

Who is the study for?
This trial is for patients having coronary artery bypass or valve surgery with cardiopulmonary bypass. Excluded are those with infections like sepsis, emergency cases, certain heart valve issues, repeat surgeries, severe heart or kidney problems, recent aspirin/Plavix use, or expected additional procedures.Check my eligibility
What is being tested?
The study tests the effects of using varying amounts of Pentaspan (a synthetic pentastarch) during open-heart surgery. It looks at how this impacts bleeding, blood clotting ability and overall fluid management in the patient's recovery process.See study design
What are the potential side effects?
Potential side effects may include altered coagulation leading to more bleeding or clotting issues and changes in fluid balance which could affect urine output and overall fluid retention.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am having heart surgery that requires a heart-lung machine.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
fluid balance
transfusion requirements
Secondary outcome measures
coagulation parameters
mediastinal drainage
postoperative bleeding
+1 more

Find a Location

Who is running the clinical trial?

Hamilton Health Sciences CorporationLead Sponsor
368 Previous Clinical Trials
300,993 Total Patients Enrolled
Irene Cybulsky, MDPrincipal InvestigatorMcMaster University

Media Library

Pentastarch (Fluid Replacement) Clinical Trial Eligibility Overview. Trial Name: NCT00182377 — N/A
Cardiac Surgery Research Study Groups:
Cardiac Surgery Clinical Trial 2023: Pentastarch Highlights & Side Effects. Trial Name: NCT00182377 — N/A
Pentastarch (Fluid Replacement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00182377 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Pentastarch Use in Cardiac Surgery
2024. "Pentastarch Use in Cardiac Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00182377.
~233 spots leftby Apr 2025
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