Light Therapy for Meibomian Gland Dysfunction

(LLLT in Peds Trial)

Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Illinois College of Optometry

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate the effectiveness of a special light therapy, known as low-level light treatment, for children with dry eye disease and Meibomian gland dysfunction (a condition affecting the eyelid glands and eye moisture). Researchers plan to compare the outcomes of light therapy with traditional methods like warm compresses and artificial tears. The light therapy involves a mask with red light to enhance gland function without using any gel. Children with severe gland issues may be suitable candidates for the trial. As an unphased trial, this study provides a unique opportunity for children to potentially benefit from an innovative treatment approach.

Do I need to stop my current medications for the trial?

The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this light therapy is safe for treating Meibomian gland dysfunction?

Research shows that low-level light therapy (LLLT) safely treats meibomian gland dysfunction (MGD), a common cause of dry eyes. This treatment improves the function of the eyelid glands that keep eyes moist.

Participants who tried LLLT reported positive results, such as more stable tears and less discomfort from dry eyes. The treatment is non-invasive, involving no surgery or needles, and is quick, taking about 15 minutes per session.

Studies have not identified any major safety concerns, but this treatment has not been tested in children. Overall, research suggests that LLLT is well-tolerated and effective for adults.12345

Why are researchers excited about this trial?

Researchers are excited about low level light treatment (LLLT) for Meibomian Gland Dysfunction because it offers a new approach compared to traditional methods like warm compresses and artificial tears. Unlike these standard treatments, LLLT uses light energy to stimulate the glands and improve their function directly. This innovative method could potentially provide faster and more effective relief by enhancing the natural production of essential oils in the eyes, addressing the root cause of the condition rather than just alleviating symptoms.

What evidence suggests that low level light treatment is effective for dry eye disease?

Research has shown that low-level light therapy (LLLT), which participants in this trial may receive, can help treat dry eye disease caused by issues with the Meibomian glands. These glands produce oil that keeps the eyes moist. Studies have found that LLLT improves the quality and flow of this oil, preventing dryness and irritation. By boosting gland activity and reducing inflammation on the eye's surface, LLLT may provide noticeable relief. This is especially promising for individuals who continue to experience dry eye symptoms despite using warm compresses and artificial tears, which is the treatment for another group in this trial.23467

Are You a Good Fit for This Trial?

This trial is for children with Meibomian Gland Dysfunction, a condition that can cause dry eyes and eyelid inflammation. Participants should have symptoms of Dry Eye Disease and be able to undergo treatments like Low Level Light Therapy without any known contraindications.

Inclusion Criteria

Subjects with severe MGD

Exclusion Criteria

Autoimmune disease
Disfiguring eye trauma
Currently pregnant or nursing
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either LLLT with warm compress and artificial tear or warm compress and artificial tear alone

4 weeks
Weekly visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Low level light treatment
Trial Overview The study tests the effectiveness of Low Level Light Therapy (LLLT) using an LED mask against traditional treatments—warm compresses and artificial tears—in treating pediatric Dry Eye Disease and Meibomian Gland Dysfunction.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: LLLTExperimental Treatment1 Intervention
Group II: warm compress and artificial tearPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Illinois College of Optometry

Lead Sponsor

Trials
8
Recruited
340+

Citations

One-year outcome of intense pulsed light therapy for ...IPL therapy is effective for treating refractory MGD in both glaucoma and non-glaucoma patients, with significant improvements in dry eye symptoms, tear film ...
Low-level light therapy alone versus combination ...Both modalities improved meibum expressibility following 3 treatment sessions, although improvement remained at final follow-up only with LLLT ...
Effect of Low-Level Light Therapy on Ocular Surface ...The treatment is designed to stimulate meibomian gland activity, improve tear film stability, reduce ocular surface inflammation. This protocol is unique ...
4.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/37026310/
A randomized controlled study evaluating outcomes of ...Conclusion: The results show that a combined therapy of IPL with LLT is effective in treating MGD with EDE compared to controls, and repeated treatment sessions ...
Effect of low‐level light therapy in individuals with dry eye ...Note: A statistically significant difference in meibum quality score was observed over time after low-level light therapy. No statistically ...
A randomized controlled study evaluating outcomes of ...The intense pulse light therapy with low-level light therapy has shown good results for the treatment of MGD and evaporative dry eye. Cumulative ...
Effectiveness and safety of intense pulsed light therapy for ...Intense pulsed light therapy probably results in a clinically relevant reduction in dry eye symptoms associated with MGD when compared to no treatment.
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