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Low Glutamate diet for Juvenile Epilepsy

N/A
Waitlist Available
Led By Kathleen Holton, MPH, PhD
Research Sponsored by American University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 month post treatment
Awards & highlights

Study Summary

This study is evaluating whether a diet low in glutamate may help reduce seizures in children with epilepsy.

Eligible Conditions
  • Diet Intervention
  • Epilepsy
  • Juvenile Epilepsy
  • Randomized Controlled Trials
  • Childhood Epilepsy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 month post treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1 month post treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in seizure duration
Change in seizure frequency
Change in seizure severity
Secondary outcome measures
Examine change in resting state brain waves after 1-month on the low glutamate diet
The effect of a 1-month low-glutamate diet on cognitive functioning in children with epilepsy.
The effect of a 1-month low-glutamate diet on quality of life in children with epilepsy.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Low Glutamate dietExperimental Treatment1 Intervention
Participants are put on the low glutamate diet for one month. The low glutamate diet reduces the consumption of free glutamate, while optimizing dietary micronutrient and antioxidant intake.
Group II: Wait-listed controlActive Control1 Intervention
Participants continue care as usual. All all medications must be kept constant during the study period, unless medically necessary.

Find a Location

Who is running the clinical trial?

American UniversityLead Sponsor
19 Previous Clinical Trials
4,720 Total Patients Enrolled
Children's National Research InstituteOTHER
211 Previous Clinical Trials
208,112 Total Patients Enrolled
Kathleen Holton, MPH, PhDPrincipal Investigator - American University
American University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
Kathleen Holton 2020. "The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04545346.
~10 spots leftby Apr 2025
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