Spatial Scene Recognition for Temporal Lobe Epilepsy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how individuals with temporal lobe epilepsy recognize familiar scenes and remember places, using a virtual tour as the main activity (known as the Virtual Tour Recognition Memory Task). The research aims to identify which brain regions are involved in this type of memory and how epilepsy affects it, aiding in the prediction and prevention of memory issues after epilepsy surgery. Participants include individuals with temporal lobe epilepsy or lesions who are considering or have undergone epilepsy surgery, as well as healthy adults for comparison. This study may suit those experiencing epilepsy-related memory issues and undergoing evaluations for epilepsy surgery. As an unphased trial, it offers a unique opportunity to enhance understanding of memory challenges in epilepsy, potentially benefiting future treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What prior data suggests that the Virtual Tour Recognition Memory Task is safe for participants?
In a previous study, researchers examined how virtual reality tasks affect memory in people with temporal lobe epilepsy. They found no noticeable changes in thinking skills between different groups. This suggests that the Virtual Tour Recognition Memory Task is manageable for participants.
The task involves recognizing and remembering scenes, a straightforward activity. It doesn't require medication or physical procedures, typically resulting in fewer risks. Participants in similar studies completed the task without reported problems.
Overall, evidence indicates that this task is safe for research use.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores innovative ways to understand and potentially improve memory function in people with temporal lobe epilepsy. Unlike typical treatments that focus on medication or surgery, this trial uses a Virtual Tour Recognition Memory Task to study how patients process spatial scenes. By combining this behavioral task with advanced imaging techniques like MRI and EEG, the researchers aim to map brain activity and identify specific areas involved in memory. This approach could lead to more targeted therapies that enhance cognitive functions, offering new hope for those affected by temporal lobe epilepsy.
What evidence suggests that the Virtual Tour Recognition Memory Task is effective for spatial scene recognition in temporal lobe epilepsy?
Studies have shown that people with temporal lobe epilepsy often struggle with memory, particularly in recognizing and remembering places. Research has linked these memory problems to specific brain areas affected by the condition. In this trial, the Virtual Tour Recognition Memory Task examines these memory issues across different participant groups. One study found that people with temporal lobe epilepsy scored lower on memory tests compared to healthy individuals. This task aids in understanding how these memory problems relate to brain structure and function. Additionally, early findings suggest that understanding these memory processes could lead to better treatments and outcomes for people with epilepsy.678910
Are You a Good Fit for This Trial?
This trial is for people with temporal lobe epilepsy or lesions who are being evaluated for epilepsy surgery, as well as healthy volunteers. Participants may have memory problems related to spatial scenes and orientation.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Lesion-Symptom Mapping
Patients with temporal lobe lesions undergo virtual tour task and voxel-based lesion-symptom mapping
Scalp ERP Study
Healthy participants perform virtual tour task during scalp EEG/ERP recording and eye tracking
Intracranial EEG
Patients undergoing SEEG for clinical seizure localization participate in virtual tour task with intracranial EEG monitoring
Follow-up
Participants are monitored for cognitive outcomes and repeat testing at six months and one year post-surgery
What Are the Treatments Tested in This Trial?
Interventions
- Virtual Tour Recognition Memory Task
Trial Overview
Researchers are using MRI scans, neuropsychological tests, a virtual reality memory task, and in some cases brain wave recordings (EEG) during surgery to study how the brain processes spatial scene recognition and memory.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Patients with epilepsy undergoing clinically indicated SEEG (n≈80) at UC Davis Medical Center. Behavioral Intervention: Virtual Tour Recognition Memory Task; Other Intervention: Intracranial EEG recording via clinically placed electrodes, a minority of which have research microelectrodes (FDA-approved Dixi micro-macro or Behnke-Fried Ad-Tech electrodes)
Healthy participants (n=80) recruited from UC Davis campus community. Intervention: Behavioral: Virtual Tour Recognition Memory Task (still-image version) during Scalp EEG/ERP recording and eye tracking
Patients with temporal lobe lesions (n≈310) and healthy controls (n≈150) at Emory University. Retrospective cohort with existing surgical lesions plus prospectively enrolled new surgical patients (\~60 over 5 years). Intervention(s): Behavioral: Virtual Tour Recognition Memory Task; Diagnostic: MRI neuroimaging and neuropsychological assessment
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
Emory University
Collaborator
Citations
Memory Deficit in Patients With Temporal Lobe Epilepsy - PMC
Objective: To explore quantitative measurements of the visual attention and neuroelectrophysiological relevance of memory deficits in temporal ...
Spatial recognition memory in a virtual reality task is ...
The medical management has no optimal results in up to one-third of the patients [1]. Many of them, with refractory temporal lobe epilepsy, are candidates for ...
Memory Deficit in Patients With Temporal Lobe Epilepsy
Objective: To explore quantitative measurements of the visual attention and neuroelectrophysiological relevance of memory deficits in temporal ...
memory and metamemory in patients with temporal lobe ...
TLE patients presented with a clear episodic memory deficit compared with controls yet preserved metamemory abilities. Experiments 2 and 3 explored the ...
Support vector machines predict postoperative memory ... - PMC
This study aims to investigate whether it is possible to predict the side of epilepsy as well as the preoperative and postoperative verbal and nonverbal memory ...
Spatial recognition memory in a virtual reality task is ...
Spatial recognition memory in a virtual reality task is altered in refractory temporal lobe epilepsy ... Data collected showed that groups did not differ ...
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy ...
019 Reduced activations within right mesial temporal lobe ...
Rationale: Epilepsy surgery is an effective treatment for Temporal lobe epilepsy (TLE), however memory decline occurs in up to 40% of people.
Lobectomy vs. MRgLITT in Temporal Lobe Epilepsy (TLE)
Conclusions: Patients who underwent MRgLITT performed significantly better on the vestibular-dependent spatial orientation task (TCT) compared to those who ...
The Effects of Temporal Lobe Epilepsy on Scene-Encoding
The RMF is a facial recognition task on which participants view photos of 50 unfamiliar men, and memory for these faces is tested immediately with a forced- ...
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