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Exposure Therapies for Anxiety Disorders (OptEx Trial)

N/A
Recruiting
Led By Michelle G Craske, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 to 65
Either stabilized on psychotropic medications or medication-free
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-treatment to post-treatment (10 weeks), to follow-up (24 weeks)
Awards & highlights

OptEx Trial Summary

This trial will compare two different approaches to exposure therapy to see which is more effective in reducing fear and anxiety in people with social anxiety disorder or panic disorder.

Who is the study for?
This trial is for adults aged 18-65 with social anxiety or panic disorder, who are either stable on current medications or not taking any. They must have access to telehealth and speak English. It's not for those with bipolar, psychosis, brain damage, recent substance abuse, serious medical conditions including pregnancy, concurrent anxiety therapy, or a history of suicidal behavior.Check my eligibility
What is being tested?
The study compares two types of exposure therapy: Inhibitory Learning-Based Exposure and Habituation-Based Exposure. The goal is to see which method better reduces fear and anxiety in participants through remote treatment sessions.See study design
What are the potential side effects?
Exposure therapies may temporarily increase anxiety levels during early stages as part of the therapeutic process. There might also be discomfort recalling anxious situations but no physical side effects are expected from these psychological treatments.

OptEx Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 65 years old.
Select...
My mental health medication is stable or I am not taking any.

OptEx Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-treatment to post-treatment (10 weeks) and follow-up (24 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-treatment to post-treatment (10 weeks) and follow-up (24 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in clinician-rated severity of social anxiety or panic disorder
Change in self-reported symptom severity of social anxiety or panic disorder
Secondary outcome measures
Anxiety Sensitivity Index (ASI-3)
Behavioral Avoidance Test (BAT)
Change in fear extinction generalization as measured by expectancy of unconditional stimuli during conditional stimuli presentation.
+8 more

OptEx Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Inhibitory Learning-Based ExposureExperimental Treatment1 Intervention
Participants will receive exposure therapy aimed at increasing inhibitory learning.
Group II: Habituation-Based ExposureActive Control1 Intervention
Participants will receive exposure therapy aimed at reducing fear responding.

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,530 Previous Clinical Trials
10,278,112 Total Patients Enrolled
Michelle G Craske, PhDPrincipal InvestigatorUniversity of California, Los Angeles
2 Previous Clinical Trials
235 Total Patients Enrolled

Media Library

Habituation-Based Exposure Clinical Trial Eligibility Overview. Trial Name: NCT04048824 — N/A
Social Anxiety Disorder Research Study Groups: Inhibitory Learning-Based Exposure, Habituation-Based Exposure
Social Anxiety Disorder Clinical Trial 2023: Habituation-Based Exposure Highlights & Side Effects. Trial Name: NCT04048824 — N/A
Habituation-Based Exposure 2023 Treatment Timeline for Medical Study. Trial Name: NCT04048824 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I qualified to participate in this clinical experiment?

"This clinical trial seeks 120 participants who have been diagnosed with panic attacks and are between 18-65 years of age."

Answered by AI

Could you tell me the magnitude of participants in this trial?

"Affirmative. The information accessible on clinicaltrials.gov demonstrates that this medical experiment is presently active, having been first posted in August 2015 and most recently updated in March 2022. It requires the enrollment of 120 participants across a single site."

Answered by AI

Is the eligibility criterion for this experiment restricted to those over thirty years of age?

"The requirements to participate in this medical trial are that applicants must be between 18 and 65 years old. Meanwhile, there exists 327 trials for minors and 830 trials available for those over the retirement age."

Answered by AI

What aims is this clinical trial hoping to achieve?

"This medical trial's primary target of evaluation is the alteration in self-reported severity of social anxiety or panic disorder. The investigation will span 10 weeks pre-treatment and 24 weeks post-treatment. Secondary objectives encompass changes to perceived likelihood/consequence, affect, and duration/subjective fear during public speaking as measured by Probability and Cost Questionnaire (PCQ), Positive and Negative Affect Schedule (PANAS 20 item) ,and Behavioral Avoidance Test (BAT)."

Answered by AI

Are there any openings left to participate in this research?

"Affirmative. According to clinicaltrials.gov, this medical trial is still recruiting and was first posted on August 14th 2015 with the latest update occurring March 21st 2022. A total of 120 individuals are required at 1 centre for the study's completion."

Answered by AI

Who else is applying?

What state do they live in?
Virginia
Georgia
California
How old are they?
18 - 65
65+
What site did they apply to?
University of California, Los Angeles
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
Recent research and studies
clinicaltrials.govStudy
Optimizing Exposure Therapy for Anxiety Disorders
Michelle Craske 2015. "Optimizing Exposure Therapy for Anxiety Disorders". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04048824.
All > Anxiety Disorder > Social Anxiety
~1 spots leftby Jun 2024
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