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Glutamate Imaging and Cognitive Testing for Depression

N/A
Recruiting
Led By Irina Esterlis, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Medication-free for at least 2 weeks or medicated with a permissible medication for acute depressed subjects
Clinical diagnosis of a current depressive episode for acute depressed subjects
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion date, an average of 4 years.
Awards & highlights

Study Summary

This trialstudies how glutamate affects depression and requires MRI/PET scans, cognitive testing, and 1-2 months of participation.

Who is the study for?
This trial is for adults aged 18-65 with certain psychiatric conditions like depression, bipolar disorder, or PTSD. It's also open to healthy individuals without any DSM-5 diagnosis. Participants must be English-speaking and medication-free or on approved meds for at least two weeks.Check my eligibility
What is being tested?
The study examines the glutamate system in mental health by using PET scans, MRI imaging, and cognitive tests over 1-2 months. The goal is to understand how this system differs among those with psychiatric disorders compared to healthy controls.See study design
What are the potential side effects?
While not a treatment trial, procedures may include discomfort from lying still during scans, potential anxiety from enclosed spaces in MRI machines, and exposure to radiation within FDA limits.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I haven't taken any medication for the last 2 weeks or only allowed medications for depression.
Select...
I am currently experiencing a depressive episode.
Select...
I have been diagnosed with PTSD according to DSM-5 criteria.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion date, an average of 4 years.
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion date, an average of 4 years. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Evidence of glutamate availability (mGluR5) in psychiatric disorders confirmed by MRI and PET data.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive TestingExperimental Treatment1 Intervention
Cognitive assessments
Group II: Magnetic Resonance ImagingActive Control1 Intervention
All subjects will have one MRI with a possibility of one functional MRI (fmri).
Group III: Positron Emission TomographyActive Control1 Intervention
All subjects will have PET scan using FPEB or ABP688.

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,853 Previous Clinical Trials
2,738,381 Total Patients Enrolled
VA Office of Research and DevelopmentFED
1,611 Previous Clinical Trials
3,305,104 Total Patients Enrolled
Irina Esterlis, PhDPrincipal InvestigatorYale School of Medicine
3 Previous Clinical Trials
299 Total Patients Enrolled

Media Library

MRI (Other) Clinical Trial Eligibility Overview. Trial Name: NCT02727972 — N/A
MRI (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02727972 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Cognitive Testing, Magnetic Resonance Imaging, Positron Emission Tomography
Post-Traumatic Stress Disorder Clinical Trial 2023: MRI Highlights & Side Effects. Trial Name: NCT02727972 — N/A
Post-Traumatic Stress Disorder Patient Testimony for trial: Trial Name: NCT02727972 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are recruitment efforts underway for this research initiative?

"Confirmed, this trial is presently enrolling patients. The information was first published online on August 1st 2011 and the update occurred October 12th 2022, based off of clinicaltrials.gov."

Answered by AI

May I join this particular experiment?

"This clinical trial is recruiting 180 individuals aged 18-65 with manic disorder who have not been diagnosed with any other DSM-5 conditions. Furthermore, each participant has to be unmedicated for at least two weeks or taking a permissible medication."

Answered by AI

Are individuals aged 45 and older eligible to be participants in this experiment?

"This medical trial has a limited age range of 18 to 65. However, for those outside this demographic, there are 495 trials available for minors and 1573 studies open to seniors."

Answered by AI

What is the aggregate number of participants in this research endeavor?

"Confirmed, the information on clinicaltrials.gov shows that this trial is actively seeking participants. The study was first posted on August 1st 2011 and updated most recently on October 12th 2022. 180 individuals are needed for enrollment at one medical centre."

Answered by AI

Who else is applying?

What state do they live in?
Connecticut
What site did they apply to?
PET Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0

What questions have other patients asked about this trial?

What exactly are you planning on doing on this trial?
PatientReceived no prior treatments

Why did patients apply to this trial?

I have taken and still take lots of meds and they don't work! If you can help that would be great!
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Examination of Glutamate and mGluR5 in Psychiatric Disorders
2011. "Examination of Glutamate and mGluR5 in Psychiatric Disorders". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02727972.
All > Mental Illness > Paid Studies Connecticut
~16 spots leftby Aug 2025
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