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Diagnostic Test

Glucose Tolerance Testing for Diabetes Risk in Children

N/A
Recruiting
Led By Sonia Caprio, MD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 7-21
Family history of type 2 diabetes mellitus
Timeline
Screening 3 weeks
Treatment Varies
Follow Up completed at baseline measurement
Awards & highlights

Study Summary

This trial looks at how common diabetes is in children who are either skinny with a family history of diabetes, or overweight/obese with or without a family history of diabetes.

Who is the study for?
This trial is for children aged 7-21 who either have a family history of type 2 diabetes or are overweight/obese. It's not open to kids on certain meds that affect blood sugar, those with other hormonal disorders, or those treated with steroids, antirejection drugs, or chemotherapy.Check my eligibility
What is being tested?
The study aims to find out how common carbohydrate intolerance is in lean and overweight/obese kids by using an Oral Glucose Tolerance Test (OGTT). This test involves drinking a sugary solution and measuring blood sugar levels at intervals.See study design
What are the potential side effects?
An OGTT can cause side effects like feeling sick, bloated, lightheadedness due to fasting before the test and the sudden intake of glucose. Some may also experience low blood sugar after the test.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 7 and 21 years old.
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My family has a history of type 2 diabetes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline measurements
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline measurements for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Glucose Tolerance
Secondary outcome measures
Insulin resistance
Other outcome measures
Gene Expression

Trial Design

2Treatment groups
Experimental Treatment
Group I: Obese/overweight chldren/adolescentsExperimental Treatment1 Intervention
Obese or overweight children and adolescents between ages 7-21 that are at risk for developing type 2 diabetes will undergo an Oral Glucose Tolerance test (OGTT) to asses glucose status.
Group II: Lean children/adolescentsExperimental Treatment1 Intervention
Lean children/adolescents between the ages of 7-21. This cohort should have family members that have type 2 diabetes or was the result of a gestational diabetes pregnancy. They will undergo an Oral Glucose Tolerance Test to assess glucose status.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oral Glucose tolerance test
2015
N/A
~20

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,841 Previous Clinical Trials
2,732,527 Total Patients Enrolled
59 Trials studying Obesity
246,148 Patients Enrolled for Obesity
National Institutes of Health (NIH)NIH
2,682 Previous Clinical Trials
6,928,798 Total Patients Enrolled
101 Trials studying Obesity
23,720 Patients Enrolled for Obesity
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,953 Previous Clinical Trials
2,658,480 Total Patients Enrolled
104 Trials studying Obesity
95,072 Patients Enrolled for Obesity

Media Library

Oral Glucose Tolerance Test (Diagnostic Test) Clinical Trial Eligibility Overview. Trial Name: NCT01967849 — N/A
Obesity Research Study Groups: Obese/overweight chldren/adolescents, Lean children/adolescents
Obesity Clinical Trial 2023: Oral Glucose Tolerance Test Highlights & Side Effects. Trial Name: NCT01967849 — N/A
Oral Glucose Tolerance Test (Diagnostic Test) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01967849 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is eligible to be involved in this research investigation?

"To qualify for this trial, 2000 individuals aged 7 to 21 who are obese must be accepted."

Answered by AI

Is participation in this medical trial open to individuals who are 45 years or older?

"As indicated by the requirements for this research, only participants aged between 7 and 21 can be enrolled in this trial."

Answered by AI

Is there currently the opportunity to join this experiment?

"Yes, the listing on clinicaltrials.gov attests that this trial is actively recruiting patients. It was initially announced in September of 1999 and was most recently updated on 13th September 2022."

Answered by AI

How many individuals are enrolled in this research endeavor?

"Affirmative, the information available on clinicaltrials.gov indicates that this experiment is actively recruiting participants. It was initially posted in September 1999 and underwent its last update on September 13th 2022. 2000 volunteers are required to be recruited from one medical centre."

Answered by AI
~109 spots leftby Sep 2025