84 Participants Needed

Exercise for Type 2 Diabetes

(RESIST Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida
Must be taking: Anti-diabetic medications
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to collect data to help researchers identify factors that prevent certain individuals from receiving the beneficial effects of exercise.

Will I have to stop taking my current medications?

If you are currently taking anti-diabetic medications, you must be willing to stop using them for the duration of the study. If you are on other medications, the trial protocol does not specify whether you need to stop them.

Is exercise safe for people with type 2 diabetes?

Exercise is generally safe for people with type 2 diabetes if certain precautions are taken. It's important to consider individual health conditions like heart disease, diabetic foot, and blood sugar levels before starting an exercise program. Consulting with healthcare providers and following guidelines can help minimize the risk of injuries and adverse events.12345

How does exercise differ from other treatments for type 2 diabetes?

Exercise is a unique treatment for type 2 diabetes because it is non-pharmacological, meaning it doesn't involve medication, and it helps improve insulin sensitivity and glycemic control (blood sugar management) through regular physical activity. Unlike medications, exercise also offers additional benefits like improved cardiovascular fitness, reduced body fat, and enhanced muscle strength, making it a comprehensive approach to managing diabetes.46789

What data supports the effectiveness of the treatment Exercise, Physical Activity, Workout, Fitness Training for Type 2 Diabetes?

Research shows that regular exercise can significantly improve blood sugar control, reduce the risk of heart problems, and enhance overall health in people with Type 2 diabetes. Exercise is as effective as some medications in managing diabetes, and combining aerobic and resistance exercises can maximize these benefits.1011121314

Who Is on the Research Team?

LM

Lauren M Sparks, PhD

Principal Investigator

Translational Research Institute for Metabolism and Diabetes

Are You a Good Fit for This Trial?

This trial is for adults aged 30-65 with Type 2 Diabetes, who are not currently exercising regularly. Participants can be on certain diabetes medications like metformin but must stop them during the study. They should have an HbA1c level that reflects moderate blood sugar control and be willing to exercise daily for the study period.

Inclusion Criteria

My HbA1c level is between 6.0% and 8.5%, or it's 8.5% or below if I'm on diabetes medication.
I am willing to stop my diabetes medication during the study.
My latest HbA1c level is between 5.7% and 8.8%, or below 8.9% if I'm on diabetes medication.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 10 weeks of aerobic exercise to study exercise resistance

10 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Exercise
Trial Overview The trial is studying how exercise affects individuals with Type 2 Diabetes. Researchers want to understand why some people don't get the usual benefits from physical activity. Participants will engage in a prescribed exercise routine throughout the study.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: ExerciseExperimental Treatment1 Intervention
10 weeks of aerobic exercise
Group II: Active ControlActive Control1 Intervention
Young athletes as a trained control

Find a Clinic Near You

Who Is Running the Clinical Trial?

Translational Research Institute for Metabolism and Diabetes, Florida

Lead Sponsor

Trials
41
Recruited
3,600+

AdventHealth Translational Research Institute

Lead Sponsor

Trials
51
Recruited
5,900+

American Diabetes Association

Collaborator

Trials
148
Recruited
102,000+

Published Research Related to This Trial

Structured endurance exercise can significantly improve glycemic control, insulin sensitivity, and cardiovascular risk factors in individuals with Type 2 diabetes, showing effects comparable to standard medications.
While exercise is beneficial, adherence to structured programs can be challenging, and more research is needed to understand the impact of lifestyle-based physical activity and the specific types and amounts of exercise that are most effective.
Revisiting the role of physical activity and exercise in the treatment of type 2 diabetes.Tudor-Locke, CE., Bell, RC., Meyers, AM.[2019]
Structured exercise is crucial for managing Type 2 diabetes, as it helps improve glycemic control and reduces cardiovascular risks, aligning with current clinical guidelines that support exercise as a therapeutic intervention.
Patients with Type 2 diabetes should engage in tailored exercise programs, with a focus on addressing cardiovascular and musculoskeletal issues, as well as motivational factors, to enhance long-term adherence and treatment effectiveness.
Exercise therapy in type 2 diabetes.Praet, SF., van Loon, LJ.[2021]
Physical activity is a crucial and effective therapy for improving outcomes in patients with type 2 diabetes mellitus (T2DM), yet it is often underutilized due to inadequate emphasis from healthcare professionals.
An effective exercise prescription for T2DM should be personalized, considering the type, frequency, intensity, duration, and progression of activities to ensure safety and optimize patient compliance and health benefits.
Exercise prescription and the patient with type 2 diabetes: a clinical approach to optimizing patient outcomes.Waryasz, GR., McDermott, AY.[2010]

Citations

Revisiting the role of physical activity and exercise in the treatment of type 2 diabetes. [2019]
Exercise therapy in type 2 diabetes. [2021]
Exercise prescription and the patient with type 2 diabetes: a clinical approach to optimizing patient outcomes. [2010]
Physical activity and type 2 diabetes. Recommandations of the SFD (Francophone Diabetes Society) diabetes and physical activity working group. [2013]
The Role of Individualized Exercise Prescription in Type 2 Diabetes Mellitus Management. [2022]
Prevention of exercise-related injuries and adverse events in patients with type 2 diabetes. [2013]
Adverse events among high-risk participants in a home-based walking study: a descriptive study. [2022]
Resources to Guide Exercise Specialists Managing Adults with Diabetes. [2020]
Diet and exercise in type 2 diabetes mellitus. [2019]
[Exercise prescription for diabetics: more than a general recommendation]. [2008]
[Physical activity as a therapeutic tool in type 2 diabetes: the rationale]. [2019]
12.United Statespubmed.ncbi.nlm.nih.gov
American College of Sports Medicine position stand. Exercise and type 2 diabetes. [2022]
13.United Statespubmed.ncbi.nlm.nih.gov
May the force be with you: why resistance training is essential for subjects with type 2 diabetes mellitus without complications. [2019]
[Individualized exercise training prescription for patients with type 2 diabetes mellitus]. [2011]
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