Food Effects on Blood Sugar Levels

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Stanford University

Must not be taking: Antihyperglycemics, Diabetogenics, Weight loss

Disqualifiers: CVD, Malignancy, Kidney/liver disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

100 Participants Needed

Trial Summary

What is the purpose of this trial?

This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating. A continuous glucose monitors (CGMs) will be used to observe how individuals respond to specific meals and drinks (e.g., Oral Glucose Tolerance Test, OGTT). By studying these patterns, the investigators hope to identify different types of metabolism and see if certain foods or food ingredients (like fiber, amino acids, or vinegar) can help control blood sugar better for specific groups. This research will help lay the groundwork for personalized dietary advice based on a person's unique biology.

Eligibility Criteria

This trial is for people with Type 2 Diabetes, Prediabetes, or those who are healthy and interested in how their bodies respond to food. Participants will be monitored to see how different foods affect their blood sugar levels.

Inclusion Criteria

Willing to provide written informed consent for all study procedures

BMI (body mass index) >19 kg/m2 but < 45 kg/m2

I can travel to Stanford for appointments.

Exclusion Criteria

Pregnancy/lactation

Heavy alcohol use

Physical activity >2 hours/day

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline

Participants provide baseline samples including stool and baseline glucose levels

1 day

1 visit (in-person)

Diet Cycles

Participants consume pre-portioned foods with different mitigators and use CGM to monitor glucose response

Multiple days

Daily monitoring (remote)

Follow-up

Participants are monitored for safety and effectiveness after the diet cycles

4 weeks

Treatment Details

Interventions

• Post prandial testing

Trial Overview The study tests individual responses to various foods using continuous glucose monitors (CGMs). It aims to understand the impact of meals and drinks on blood sugar levels and identify personalized dietary recommendations.

Participant Groups

Group I: Diet Cycles Experimental Treatment 1 Intervention

Participants will be asked to consume pre-portioned foods on different days as the first meal of the day, use a CGM, and take saliva and micro samples of blood before and after each meal.

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials

2,527

Recruited

17,430,000+