74 Participants Needed

Exercise for Obesity

LS
LJ
Overseen ByLaurie J Goodyear, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to determine whether exercise training leads to changes in the white adipose tissue that are beneficial to the body's regulation of sugar and body weight.

Who Is on the Research Team?

LJ

Laurie J Goodyear, PhD

Principal Investigator

Joslin Diabetes Center

Are You a Good Fit for This Trial?

This trial is for adults aged 25-55 with varying body weights and conditions: healthy, overweight, obese, or with type 2 diabetes. Participants should have a BMI within certain ranges depending on their health status and controlled HbA1c levels. Those pregnant, on specific medications, with severe hypertension or other serious health issues are excluded.

Inclusion Criteria

Your HbA1c levels should be within a certain range, depending on your weight and whether you have type 2 diabetes.
Your body mass index (BMI) needs to be within a certain range based on your weight and height.
I am between 25 and 55 years old.

Exclusion Criteria

I am younger than 25 or older than 55 years old.
I am on a basal-bolus insulin treatment plan.
I am currently taking beta-blockers or thiazolidinediones.
See 16 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 10-week exercise program with varying intensity based on their group assignment

10 weeks

Follow-up

Participants are monitored for changes in adipose tissue characteristics and metabolic homeostasis after the exercise program

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Exercise Intervention
Trial Overview The study investigates how exercise affects white adipose tissue (body fat) in relation to sugar regulation and weight control. It aims to understand if regular physical activity can lead to beneficial changes in the body's handling of sugar among different groups of people.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Group I: Moderate Intensity Training-Overweight/Obese Type 2 DiabetesExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group II: Moderate Intensity Training-Healthy Overweight/ObeseExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group III: Moderate Intensity Training-Healthy LeanExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group IV: High Intensity Training-Healthy Lean.Experimental Treatment1 Intervention
Eligible subjects will undergo a 10-week high intensity exercise program

Find a Clinic Near You

Who Is Running the Clinical Trial?

Joslin Diabetes Center

Lead Sponsor

Trials
98
Recruited
26,500+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials
2,513
Recruited
4,366,000+
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