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Exercise for Obesity
N/A
Waitlist Available
Led By Laurie J Goodyear, PhD
Research Sponsored by Joslin Diabetes Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age: 25-55 years old at the time of screening
Be between 18 and 65 years old
Must not have
Age <25 and >55 years old
Basal-Bolus Insulin regimen
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline adipose tissue characteristics following 10 weeks of exercise training.
Awards & highlights
Summary
This trial will test whether exercise can improve how well the body regulates blood sugar and body weight.
Who is the study for?
This trial is for adults aged 25-55 with varying body weights and conditions: healthy, overweight, obese, or with type 2 diabetes. Participants should have a BMI within certain ranges depending on their health status and controlled HbA1c levels. Those pregnant, on specific medications, with severe hypertension or other serious health issues are excluded.
What is being tested?
The study investigates how exercise affects white adipose tissue (body fat) in relation to sugar regulation and weight control. It aims to understand if regular physical activity can lead to beneficial changes in the body's handling of sugar among different groups of people.
What are the potential side effects?
Since this trial involves an exercise intervention rather than medication, side effects may include typical responses to physical activity such as muscle soreness, fatigue or injury risk. However, these will vary based on individual fitness levels and the intensity of the exercise regimen.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 25 and 55 years old.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am younger than 25 or older than 55 years old.
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I am on a basal-bolus insulin treatment plan.
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I currently have a fever, body aches, or swollen glands due to an infection.
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I have kidney or liver problems.
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My blood pressure is not higher than 160/90 mmHg.
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I have Type 1 Diabetes.
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I have a heart or lung condition.
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I have had a stroke in the past.
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I have a history of HIV/AIDS or certain cancers.
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I do not have multiple sclerosis or ALS.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ change from baseline adipose tissue characteristics following 10 weeks of exercise training.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline adipose tissue characteristics following 10 weeks of exercise training.
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in human adipose tissue characteristics following exercise training.
Trial Design
4Treatment groups
Experimental Treatment
Group I: Moderate Intensity Training-Overweight/Obese Type 2 DiabetesExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group II: Moderate Intensity Training-Healthy Overweight/ObeseExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group III: Moderate Intensity Training-Healthy LeanExperimental Treatment1 Intervention
Eligible subjects will undergo a 10-week moderate intensity exercise program.
Group IV: High Intensity Training-Healthy Lean.Experimental Treatment1 Intervention
Eligible subjects will undergo a 10-week high intensity exercise program
Find a Location
Who is running the clinical trial?
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,424 Previous Clinical Trials
4,324,861 Total Patients Enrolled
466 Trials studying Obesity
589,178 Patients Enrolled for Obesity
Joslin Diabetes CenterLead Sponsor
97 Previous Clinical Trials
26,548 Total Patients Enrolled
15 Trials studying Obesity
714 Patients Enrolled for Obesity
Laurie J Goodyear, PhDPrincipal InvestigatorJoslin Diabetes Center
1 Previous Clinical Trials
10 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am younger than 25 or older than 55 years old.I am on a basal-bolus insulin treatment plan.I am currently taking beta-blockers or thiazolidinediones.I currently have a fever, body aches, or swollen glands due to an infection.I have kidney or liver problems.Your HbA1c levels should be within a certain range, depending on your weight and whether you have type 2 diabetes.You have a body mass index (BMI) of 37 or higher.You have a history of developing keloids.My blood pressure is not higher than 160/90 mmHg.You have health conditions that make it unsafe for you to do exercise testing, according to the American Heart Association.Your body mass index (BMI) needs to be within a certain range based on your weight and height.You are currently trying to lose weight or following a diet plan.You are unable to exercise at half of your expected heart rate.You have donated blood recently.I have Type 1 Diabetes.I am between 25 and 55 years old.Your HbA1c level is 9.0% or higher.I have a heart or lung condition.I have had a stroke in the past.I have a history of HIV/AIDS or certain cancers.I do not have multiple sclerosis or ALS.
Research Study Groups:
This trial has the following groups:- Group 1: High Intensity Training-Healthy Lean.
- Group 2: Moderate Intensity Training-Overweight/Obese Type 2 Diabetes
- Group 3: Moderate Intensity Training-Healthy Overweight/Obese
- Group 4: Moderate Intensity Training-Healthy Lean
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Obesity Patient Testimony for trial: Trial Name: NCT03133156 — N/A
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