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Vitamin Supplement

BBB function, cognition, and mood in T2DM adults with Thiamine treatment. for Type 2 Diabetes

N/A

Waitlist Available

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after 3 months

Awards & highlights

Study Summary

This trial aims to investigate if taking vitamin B1 capsules can help improve brain function in adults with type 2 diabetes. Participants will undergo brain scans, cognitive assessments, blood tests, and questionnaires at

Who is the study for?

This trial is for adults with Type 2 Diabetes who may have low levels of thiamine (vitamin B1). Participants will need to visit UCLA twice, three months apart, for about 2.5-3 hours each time. The eligibility criteria are not fully listed here.Check my eligibility

What is being tested?

The study is testing if taking vitamin B1 capsules (thiamine) can improve brain function in people with Type 2 Diabetes. This involves MRI scans, cognitive tests, blood work, and questionnaires over two visits.See study design

What are the potential side effects?

Potential side effects are not detailed in the provided information but generally could include reactions typical of vitamin supplements such as digestive discomfort or allergic reactions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after 3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and after 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Analyze blood serum S100β levels.

Assess anxiety in T2DM adults with thiamine treatment.

Assess if BBB function has been repaired.

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: BBB function, cognition, and mood in T2DM adults with Thiamine treatment.Experimental Treatment1 Intervention

Analyze BBB function, cognition, and mood in T2DM adults with Thiamine treatment and compare to the placebo group.

Group II: BBB function, cognition, and mood in T2DM adults without Thiamine treatment.Placebo Group1 Intervention

Analyze BBB function, cognition, and mood in T2DM adults without Thiamine treatment and compare to the Thiamine treatment group.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Thiamine

2018

Completed Phase 4

~1620

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor

1,530 Previous Clinical Trials

10,278,150 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What specific criteria must individuals meet to be eligible for enrollment in this clinical study?

"To be eligible for enrollment, individuals must possess a diagnosis of type 2 diabetes and fall within the age range of 40 to 65 years. Approximately 52 participants will be accepted into this investigation."

Answered by AI

Are participants being actively sought for this ongoing research study?

"According to the details on clinicaltrials.gov, recruitment for this specific trial is currently closed. The information was first posted on April 1st, 2024 and last updated on March 13th, 2024. Despite this trial not seeking participants presently, there are approximately 1409 other ongoing trials actively recruiting patients at present."

Answered by AI

Is there an inclusion of individuals aged over 70 years in this research study?

"Individuals aged between 40 and 65 are eligible to partake in this research. It is noted that there exists a total of 191 investigations targeting individuals under the age of majority, while 1096 studies cater to patients surpassing the age limit set for this trial."

Answered by AI

Recent research and studies

Journal of Magnetic Resonance ImagingJournal

Kumar, Rajesh, Sean Delshad, Mary A. Woo, Paul M. Macey, and Ronald M. Harper. 2011. “Age-related Regional Brain T2-relaxation Changes in Healthy Adults”. Journal of Magnetic Resonance Imaging. Wiley. doi:10.1002/jmri.22831.

Journal of Neuroscience ResearchJournal

Regional Brain Axial and Radial Diffusivity Changes During Development

Kumar, Rajesh, Haidang D. Nguyen, Paul M. Macey, Mary A. Woo, and Ronald M. Harper. 2011. “Regional Brain Axial and Radial Diffusivity Changes During Development”. Journal of Neuroscience Research. Wiley. doi:10.1002/jnr.22757.

SleepJournal

Abnormal Myelin and Axonal Integrity in Recently Diagnosed Patients with Obstructive Sleep Apnea

Kumar, Rajesh, Tiffany T. Pham, Paul M. Macey, Mary A. Woo, Frisca L. Yan-Go, and Ronald M. Harper. 2014. “Abnormal Myelin and Axonal Integrity in Recently Diagnosed Patients with Obstructive Sleep Apnea”. Sleep. Oxford University Press (OUP). doi:10.5665/sleep.3578.

Archives of General PsychiatryJournal

Focal Subcortical Biophysical Abnormalities in Patients Diagnosed with Type 2 Diabetes and Depression