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N/A

Aerobic Exercise for Type 2 Diabetes

N/A
Waitlist Available
Led By Jacob Haus, PhD
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 12 weeks
Awards & highlights

Study Summary

This trial found that aerobic exercise decreases inflammation in type 2 diabetics by reducing the activity of a protein called RAGE.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Quantify the change in basal circulating sRAGE after 12-weeks of supervised aerobic exercise training.
Secondary outcome measures
Quantify the change in aerobic capacity (VO2max) after 12-weeks of supervised aerobic exercise training.
Quantify the change in basal muscle RAGE expression after 12-weeks of supervised aerobic exercise training.
Quantify the change in insulin sensitivity after 12-weeks of supervised aerobic exercise training.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic Exercise GroupExperimental Treatment1 Intervention
Aerobic Exercise (AE) subjects will come in for supervised, aerobic exercise training sessions 5 days a week for 12 weeks. Training will progress from 55% VO2max for week 1 (40 min session), to 60-65% VO2max for week 2 (50 min session), to ~70% VO2max for all other weeks (50 min session). Subjects will perform a warm-up and cool down (~5 min each) that includes stretching exercises. Subjects will wear heart rate monitors during each training session to provide feedback of target heart rate. Intensity, duration, resting and exercise heart rates, and blood pressures will be recorded for each session. Follow-up VO2max tests will be performed at weeks 4 and 8 to monitor progress and adjust AE training intensity.
Group II: Control GroupActive Control1 Intervention
During the 12 week control period, subjects are to maintain their normal, daily-living activities. Control group participants will be given the option to enroll in the AE training group after completion of the original Control group trial period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Exercise
2013
Completed Early Phase 1
~1310

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,795 Previous Clinical Trials
6,373,886 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,357 Previous Clinical Trials
4,315,136 Total Patients Enrolled
Jacob Haus, PhDPrincipal Investigator - University of Michigan
University of Michigan
1 Previous Clinical Trials
40 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility requirements for taking part in this research?

"To participate in this trial, diabetics aged 40-75 are required. Approximately 60 people will be admitted into the study."

Answered by AI

Are there any still-available slots for individuals to participate in this research?

"Yes, the evidence on clinicaltrials.gov suggests that this particular medical study is actively seeking participants since its inception in December 2018. The trial currently requires 60 individuals to be recruited at a single location and was last updated on April 25th 2022."

Answered by AI

How many individuals are eligible to participate in this research program?

"Affirmative. Clinicaltrials.gov's records show that this medical trial is actively recruiting, with the initial posting on December 20th 2018 and a recent update on April 25th 2022. The study seeks 60 volunteers from one particular site."

Answered by AI

Is enrollment open to seniors for this trial?

"This clinical trial is seeking participants aged 40 to 75 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Exercise and the Receptor for Advanced Glycation End Products (RAGE)
Jacob Haus 2018. "Exercise and the Receptor for Advanced Glycation End Products (RAGE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03534687.
~8 spots leftby Apr 2025
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