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Lower body heating: Intervention arm in diabetics for Type 2 Diabetes

N/A
Waitlist Available
Led By Jaume Padilla, PhD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with type 2 diabetes who are overweight and obese (BMI 25-50 kg/m2), 35 to 65 years of age, and sedentary (<60 minutes structured exercise/week). Healthy volunteers without type 2 diabetes: 18 to 65 years of age.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline insulin-stimulated leg blood flow following 1 heating session, 7 days of heating intervention, or 8 weeks of walking intervention/no intervention.
Awards & highlights

Study Summary

This trial will help determine if increased walking and lower body heating can improve leg vascular function in patients with type 2 diabetes.

Eligible Conditions
  • Type 2 Diabetes
  • Obesity

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline insulin-stimulated leg blood flow following 1 heating session, 7 days of heating intervention, or 8 weeks of walking intervention/no intervention.
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline insulin-stimulated leg blood flow following 1 heating session, 7 days of heating intervention, or 8 weeks of walking intervention/no intervention. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Insulin-stimulated Leg Blood Flow Calculated as Percent Change (t0, t60)
Net Change in Insulin-stimulated Leg Blood Flow Calculated as Percent Change From Pre-intervention (t0,t60) to Post-intervention (t0,t60).

Trial Design

6Treatment groups
Experimental Treatment
Group I: Walking: No intervention in diabeticsExperimental Treatment1 Intervention
Subjects will be instructed to continue their usual lifestyle for 8 weeks.
Group II: Walking: Intervention arm in diabeticsExperimental Treatment1 Intervention
The walking program will consist of 45 minutes of walking (at a moderate pace) 5 days per week for 8 weeks.
Group III: Walking: Healthy cohort as reference controlsExperimental Treatment1 Intervention
Subjects will be studied at one time only.
Group IV: Lower body heating: Intervention arm in healthy subjectsExperimental Treatment1 Intervention
This intervention consists of 60 minutes of lower body heating (40-42 degree C).
Group V: Lower body heating: Intervention arm in diabeticsExperimental Treatment1 Intervention
This intervention consists of 60 minutes of lower body heating (40-42 degree C) 7 days per week for 7 days.
Group VI: Lower body heating: Healthy cohort as reference controlsExperimental Treatment1 Intervention
Subjects will be studied at one time only.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Walking: Intervention arm in diabetics
2017
N/A
~100
Lower body heating: Intervention arm in diabetics
2017
N/A
~100
Lower body heating: Intervention arm in healthy subjects
2017
N/A
~100

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
362 Previous Clinical Trials
628,015 Total Patients Enrolled
Jaume Padilla, PhDPrincipal Investigator - University of Missouri-Columbia
University of Missouri-Columbia
1 Previous Clinical Trials
8 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effects of Walking and Heating on Vascular Function in Diabetic Patients
Jaume Padilla 2017. "Effects of Walking and Heating on Vascular Function in Diabetic Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03203694.
~13 spots leftby Apr 2025
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