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Artificial Pancreas

NAP first, then UMPC for Type 1 Diabetes (NAP Trial)

N/A
Waitlist Available
Led By Sue A Brown, MD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 hours (two 18-hour experiments)
Awards & highlights

Summary

This trial is testing a new smart insulin system (NAP) against an existing one (UMPC) in adults using advanced insulin pumps. Both systems automatically adjust insulin based on blood sugar readings to maintain healthy levels. These systems have been developed to improve type 1 diabetes management by automating insulin delivery without needing extra doses before meals.

Eligible Conditions
  • Type 1 Diabetes

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 hours (two 18-hour experiments)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 36 hours (two 18-hour experiments) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent of Time-in-Range (TIR) on NAP versus UMPC.
Secondary outcome measures
Participant Feedback
Percent of Time in Hyperglycemia.
Percent of Time in Hypoglycemia.
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: UMPC first, then NAPExperimental Treatment2 Interventions
Participants will use the UMPC for 18 hours, then switch to NAP for 18 hours.
Group II: NAP first, then UMPCExperimental Treatment2 Interventions
Participants will use the Neural Net Artificial Pancreas (NAP) algorithm for 18 hours. Then switch to the University of Virginia Model-Predictive Control (UMPC) for 18 hours.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Neural-net Artificial Pancreas
2023
N/A
~20
University of Virginia Model Predictive Control
2023
N/A
~20

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor
761 Previous Clinical Trials
1,256,023 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,381 Previous Clinical Trials
4,315,087 Total Patients Enrolled
Boris P Kovatchev, PhDStudy DirectorUniversity of Virginia Center for Diabetes Technology
~7 spots leftby Sep 2025
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