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Vitamin D Analog
Zemplar for Type 2 Diabetes
N/A
Waitlist Available
Research Sponsored by Scott and White Hospital & Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 4 weeks, and 12 weeks
Awards & highlights
Study Summary
The purpose of this research study is to study the effects of paricalcitol on endothelial function and inflammation, cardiovascular risk factors which are associated with patient populations that have Type 2 diabetes and Stage 3 and 4 Chronic Kidney Disease (CKD). Hypothesis 1: The state of CKD is associated with oxidative stress and inflammation and impaired post ischemic endothelium dependent flow mediated vasodilation which may contribute to atherogenesis. Hypothesis 2: The administration of paracalcitol to patients with CKD will suppress oxidative stress and inflammation and improve endothelial function and thus contribute to an anti-atherogenic action.
Eligible Conditions
- Type 2 Diabetes
- Chronic Kidney Disease
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 4 weeks, and 12 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 4 weeks, and 12 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
The change in brachial artery Flow Mediated Dilataion with paracalcitol (1mcg/day)compared with placebo for 3 months.
Secondary outcome measures
Biomarker Measurement
Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: ZemplarActive Control1 Intervention
Zemplar 1 mcg or placebo to be taken once daily with breakfast for 3 months
Group II: PlaceboPlacebo Group1 Intervention
Zemplar 1 mcg or placebo to be taken once daily with breakfast for 3 months
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Who is running the clinical trial?
Scott and White Hospital & ClinicLead Sponsor
22 Previous Clinical Trials
32,424 Total Patients Enrolled
AbbottIndustry Sponsor
751 Previous Clinical Trials
478,390 Total Patients Enrolled
Frequently Asked Questions
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