30 Participants Needed

Exercise Snacks for Type 2 Diabetes

JP
Overseen ByJonathan P Little, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

To conduct a randomized crossover trial to determine the acute impact of exercise snacks on glycemic control in physically inactive individuals living with type 2 diabetes using continuous glucose monitoring.

Will I have to stop taking my current medications?

No, you won't have to stop taking your current medications. The trial requires that you maintain your current medication doses during the study.

What data supports the effectiveness of the treatment Exercise Snacks for Type 2 Diabetes?

Research shows that regular physical activity, including high-intensity interval exercise and brief bouts of exercise, can improve blood sugar control, increase insulin sensitivity, and reduce risk factors for heart disease in people with type 2 diabetes. Exercise is a key part of managing type 2 diabetes and can lead to better overall health outcomes.12345

Is it safe to participate in an 'Exercise Snacks' clinical trial for type 2 diabetes?

Exercise, including 'Exercise Snacks' or short bouts of activity, is generally safe for people with type 2 diabetes when done with proper guidance. It's important to monitor blood sugar levels before and after exercise to avoid low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia). Consulting with a healthcare provider before starting an exercise program is recommended to ensure safety, especially for those with existing health conditions.56789

How is the 'Exercise Snacks' treatment different from other treatments for type 2 diabetes?

The 'Exercise Snacks' treatment involves short, intense bursts of exercise before meals, which is different from traditional exercise routines that are longer and less frequent. This approach is designed to improve blood sugar control more effectively by integrating exercise into daily routines in a convenient and time-efficient manner.2561011

Research Team

JL

Jonathan Little, PhD

Principal Investigator

University of British Columbia

Eligibility Criteria

This trial is for inactive individuals aged 30-75 with type 2 diabetes, a BMI of 18.5-40 kg/m2, stable medication doses for the past 6 months, and an HbA1c of ≤8.5%. They must exercise less than 150 minutes per week and can maintain their current activity level and medication during the study.

Inclusion Criteria

I have been diagnosed with type 2 diabetes by a doctor.
Currently participating in less than 150 minutes of moderate-to-vigorous intensity aerobic exercise per week
Able to maintain current physical activity patterns during the study
See 10 more

Exclusion Criteria

Currently participating in another clinical trial that interferes with the study procedures
Currently pregnant or planning on becoming pregnant during the intervention (i.e., within the next 3-4 months)
Have a psychiatric disorder that could prevent you from completing the study procedures or visits
See 16 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Exercise Condition (EX)

Participants perform four 1-minute exercise snacks per day on two consecutive days

2 days
Continuous glucose monitoring

Control Condition (CON)

Participants refrain from any structured exercise on two consecutive days

2 days
Continuous glucose monitoring

Washout Period

A one-day washout period between the completion of both trials

1 day

Follow-up

Participants are monitored for safety and effectiveness after the trial

1 week

Treatment Details

Interventions

  • Exercise Snacks
Trial Overview The trial is testing 'exercise snacks'—short bursts of physical activity—to see how they affect blood sugar levels in people with type 2 diabetes. It's a randomized crossover trial using continuous glucose monitoring to track changes.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise (EX): exercise snacks conditionExperimental Treatment1 Intervention
Bodyweight-style exercise snacks lasting 1-minute each performed with vigorous effort 4 times per day on two consecutive days.
Group II: Control (CON): Non-exercise conditionActive Control1 Intervention
No structured exercise on two consecutive days.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials
1,506
Recruited
2,528,000+

McMaster University

Collaborator

Trials
936
Recruited
2,630,000+

Findings from Research

Regular physical activity can significantly reduce the risk of developing type 2 diabetes (T2D) by 50% in individuals with high metabolic risk and improve glycemic control by lowering HbA1c levels by an average of 0.7%.
The benefits of physical activity extend beyond just one-time exercise sessions, as consistent training leads to long-term improvements in blood pressure, lipid profiles, and insulin resistance, with recommendations tailored to fit individual preferences and lifestyles.
Physical activity and type 2 diabetes. Recommandations of the SFD (Francophone Diabetes Society) diabetes and physical activity working group.Duclos, M., Oppert, JM., Verges, B., et al.[2013]
In a study involving six patients with type 2 diabetes, three types of 20-minute moderate-intensity exercises (WB-EMS, RES, and END) were found to reduce postprandial glucose levels after meals, indicating that exercise can help manage blood sugar spikes.
While all exercise types showed similar effects on glucose levels over time, cycling endurance exercise (END) suggested a potential superior effect during the post-exercise recovery phase, although this was not statistically significant.
Effects of Acute Resistance Exercise with and without Whole-Body Electromyostimulation and Endurance Exercise on the Postprandial Glucose Regulation in Patients with Type 2 Diabetes Mellitus: A Randomized Crossover Study.Holzer, R., Schulte-Körne, B., Seidler, J., et al.[2022]
In a 3-year study involving 300 patients with type 2 diabetes, behavioral counseling led to significant increases in physical activity and decreases in sedentary time, which were associated with improved physical fitness and reduced cardiovascular risk factors.
Modest increases in moderate- to vigorous-intensity physical activity (MVPA) resulted in clinically meaningful improvements, such as a decrease in HbA1c levels and enhanced cardiorespiratory fitness, highlighting the importance of even small changes in activity levels.
Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes: The Italian Diabetes and Exercise Study 2 (IDES_2).Balducci, S., Haxhi, J., Sacchetti, M., et al.[2023]

References

Physical activity and type 2 diabetes. Recommandations of the SFD (Francophone Diabetes Society) diabetes and physical activity working group. [2013]
Effects of Acute Resistance Exercise with and without Whole-Body Electromyostimulation and Endurance Exercise on the Postprandial Glucose Regulation in Patients with Type 2 Diabetes Mellitus: A Randomized Crossover Study. [2022]
Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes: The Italian Diabetes and Exercise Study 2 (IDES_2). [2023]
Exercise Therapy for Patients With Type 2 Diabetes: A Narrative Review. [2020]
Diet and exercise in type 2 diabetes mellitus. [2019]
'Exercise snacks' before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance. [2022]
Programming pre-exercise snacks to prevent post-exercise hypoglycemia in intensively treated insulin-dependent diabetics. [2019]
Resources to Guide Exercise Specialists Managing Adults with Diabetes. [2020]
Exercising Tactically for Taming Postmeal Glucose Surges. [2023]
10.China (Republic : 1949- )pubmed.ncbi.nlm.nih.gov
[Applying an Exercise Snack-Based Health Promotion Strategy]. [2023]
11.United Statespubmed.ncbi.nlm.nih.gov
Glycemic and insulinemic responses to different preexercise snacks in participants with impaired fasting glucose. [2019]
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