Electroencephalographic (EEG) for Major Depressive Disorder

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, MOMajor Depressive Disorder+1 MoreElectroencephalographic (EEG) - DiagnosticTest
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trial looked at whether depression symptoms were linked with changes in brain activity caused by electroconvulsive therapy.

Eligible Conditions
  • Major Depressive Disorder
  • Electroconvulsive Therapy (ECT)

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

7 Primary · 0 Secondary · Reporting Duration: Up to 8 weeks during patients ECT treatment course

Week 8
Electroconvulsive Therapy
Density of EEG sleep spindles during first cycle of non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.
Duration of Central Positive Complexes during ECT treatments.
Duration of PGES during ECT treatments.
Interval change in Quick Inventory of Depressive Symptomatology-16 Item Self Report (QIDS-SR16) between ECT sessions.
Pittsburgh Sleep Quality Index (PSQI)
Slow wave activity (SWA) during first cycle of N3 sleep on evenings following ECT treatments

Trial Safety

Safety Progress

1 of 3

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3
Active
2
Liafensine
2
NV-5138

Trial Design

1 Treatment Group

Patients with Treatment-Resistant Depression
1 of 1

Experimental Treatment

90 Total Participants · 1 Treatment Group

Primary Treatment: Electroencephalographic (EEG) · No Placebo Group · N/A

Patients with Treatment-Resistant DepressionExperimental Group · 6 Interventions: Electroencephalographic (EEG), Closed loop acoustic stimulation (CLAS), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Ictal Electroencephalographic (EEG) Measurements, Post-Ictal Electroencephalographic (EEG) Suppression Measurements, Quantitative Measurements of Sleep Microstructure · Intervention Types: DiagnosticTest, DiagnosticTest, DiagnosticTest, DiagnosticTest, DiagnosticTest, DiagnosticTest

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 8 weeks during patients ect treatment course

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,822 Previous Clinical Trials
2,283,918 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are being referred for electroconvulsive therapy (ECT) to treat severe depression, bipolar disorder, schizophrenia or schizoaffective disorder with depression.
References

Frequently Asked Questions

How many individuals are being accepted into this medical study?

"Affirmative, the information on clinicaltrials.gov alludes to this trial's active recruitment status. This medical research was first advertised on October 9th 2020 and updated most recently on June 14th 2022; it seeks 90 individuals from a single site for participation." - Anonymous Online Contributor

Unverified Answer

Does this research endeavor need additional participants?

"Affirmative. According to clinicaltrials.gov, the study has been actively recruiting since October 9th 2020 and it was last modified on June 14th 2022. There is an urgent need for 90 individuals at one medical site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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