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EEG Markers for ECT Response in Depression

N/A

Waitlist Available

Led By MohammadMehdi Kafashan

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 years or greater

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 8 weeks during patients ect treatment course

Awards & highlights

Study Summary

This trial looked at whether depression symptoms were linked with changes in brain activity caused by electroconvulsive therapy.

Who is the study for?

This trial is for adults (18+) referred for ECT to treat resistant depression, including major depressive disorder with or without psychotic symptoms, and those with schizophrenia or schizoaffective disorder currently experiencing a depressed episode.Check my eligibility

What is being tested?

The study aims to correlate changes in depression symptoms with EEG patterns following electroconvulsive therapy. It involves measuring post-ictal EEG suppression, sleep microstructure, closed loop acoustic stimulation effects, and using the QIDS-SR16 scale.See study design

What are the potential side effects?

While not explicitly listed here, common side effects of ECT may include confusion shortly after treatment, memory loss for events surrounding the period of ECT treatment, physical side effects such as headache, muscle soreness or nausea.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 8 weeks during patients ect treatment course

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 8 weeks during patients ect treatment course

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 8 weeks during patients ect treatment course for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Electroconvulsive Therapy

Density of EEG sleep spindles during first cycle of non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.

Duration of Central Positive Complexes during ECT treatments.

+4 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Patients with Treatment-Resistant DepressionExperimental Treatment6 Interventions

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor

1,931 Previous Clinical Trials

2,299,678 Total Patients Enrolled

MohammadMehdi KafashanPrincipal Investigator - Washington University School of Medicine

Washington University School of Medicine

1 Previous Clinical Trials

50 Total Patients Enrolled

Media Library

Electroconvulsive Therapy (ECT) Clinical Trial Eligibility Overview. Trial Name: NCT04451135 — N/A

Major Depressive Disorder Research Study Groups: Patients with Treatment-Resistant Depression

Major Depressive Disorder Clinical Trial 2023: Electroconvulsive Therapy (ECT) Highlights & Side Effects. Trial Name: NCT04451135 — N/A

Electroconvulsive Therapy (ECT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04451135 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being accepted into this medical study?

"Affirmative, the information on clinicaltrials.gov alludes to this trial's active recruitment status. This medical research was first advertised on October 9th 2020 and updated most recently on June 14th 2022; it seeks 90 individuals from a single site for participation."

Answered by AI

Does this research endeavor need additional participants?

"Affirmative. According to clinicaltrials.gov, the study has been actively recruiting since October 9th 2020 and it was last modified on June 14th 2022. There is an urgent need for 90 individuals at one medical site."

Answered by AI