This trial is evaluating whether Standard psychiatry and cognitive behavioral online intervention will improve 1 primary outcome and 6 secondary outcomes in patients with Melancholia. Measurement will happen over the course of Baseline and 4 months.
This trial requires 156 total participants across 2 different treatment groups
This trial involves 2 different treatments. Standard Psychiatry And Cognitive Behavioral Online Intervention is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
A large number of other conditions and symptoms may co-exist with a diagnosis of depression and thus be considered as comorbidities as well as being associated with depression in their own right. Different diagnostic criteria for comorbid depression exist. Because of this, the term ‘depression with melancholia’ has become an umbrella term with no clear line separating these two conditions.
melancholia is a mood disorder that occurs in adolescence and has an onset age of 14 to 21 years. Affected individuals tend to have poor functioning at work and school and to have more disability as well as more hopelessness while feeling depressed. They also have more trouble in interpersonal relationships and emotional regulation. People diagnosed with melancholia experience emotional changes including: low energy, sleepiness, hypersomnia, and lethargy. They are often irritable and are more depressed.
M.I.N.G.E., a popular treatment for depression with a more favourable side effect profile than SSRIs or TCAs, has been studied in more than 200 clinical trials in over 10,000 patients. It has been shown to improve symptoms of depression, as well as symptoms of other mental health problems such as major depression, dysthymia, bipolar disorder, obsessive-compulsive disorder (OCD), and anxiety disorders. The antidepressant discontinuation syndrome is very rare and usually appears within 4 weeks of stopping treatment when patients are not taking the medication regularly as a pill. The cause has not been clarified.
Melancholia is generally reversible and may be cured using a combination of cognitive and behavioral therapy. The potential for the treatment of depressive disorders in general is uncertain, however.
Although the treatments mentioned are only part of the full list, they seem to fall into the same categories as the treatments discussed in the treatment part. The treatments that have most success are antidepressants and electroconvulsive therapy with ECT seeming to be most successful. Medication with anxiolytics and mood stabilizers appear to be quite successful, but with antidepressant-like or anxiolytic-like effects at lower doses. Other treatments that have been described are a combination of all the above treatments. However, no studies examining the efficacy of medications have been undertaken and the results in different studies were inconsistent - no conclusions could be made with regards to the efficacy of medications.
The signs of depression in the early stage of the disease can be identified as the same as those of major depressive disorder (MDD). However, as the disease advances, the symptoms of the disease, such as insomnia, forgetfulness, and low mood are more predominant than those of MDD.
The Internet can be useful in educating participants about depression and in facilitating the collection of symptom-related information that is important to the formation of a depressed diagnosis.
Anxiety does not appear to be a key factor in determining the primary subtype of melancholia: melancholic patients with panic disorders appear to have more generalized, and not anxiety-based, symptoms and to have greater impairment in functioning in their daily lives. Future studies need to examine the presence of subthreshold anxiety symptoms in melancholic patients without panic disorder and further examine the contribution of anxiety symptoms to the subtype of melancholia.
Online interventions have a long history of use in treating psychiatric conditions, particularly in the treatment of major depression. However, the evidence for such uses is weak. The evidence for the use of CBT for anxiety disorders is weak and the evidence for the use of CBT for eating disorders is inconclusive.
Though not all patients respond to antidepressants, there has been at least one new discovery for treating melancholia in recent years. There is still no consensus as to the specific treatment. It remains a difficult diagnosis but has some interesting new therapies for treating it.
In line with the growing evidence base for MBC and the limited evidence base for the use of CBT delivered online, this survey provides valuable data on the frequency of use of CBT, psychotherapy and antidepressant treatment in conjunction with mental health treatment during the year 2015-2016. This survey does not cover treatment for social anxiety/agoraphobia, substance use disorders or anorexia in patients from other than Western countries.
The most current scientific reviews and meta-analyses of antidepressant treatment effects on major depression, anxiety and mood are available. A majority of these reviews concluded that antidepressant treatment did not reduce the risk of subsequent depression, anxiety or mood instability.